Application Data
(Schematic representation of pLenti-AAVR-Puro Vector (11092 bp, Ampicillin-resistant). EcoRI Digestion: 1147 bp + 2661 bp + 7284 bp.)
pLenti-AAVR-Puro vector
pLenti-AAVR-Puro Vector
Synonyms
pLenti-AAVR-Puro; N/A; pLenti-AAVR-Puro Vector; pLenti-AAVR-Puro vector
Preparation and Storage
Store at -20 degree C.
Application Data
(Schematic representation of pLenti-AAVR-Puro Vector (11092 bp, Ampicillin-resistant). EcoRI Digestion: 1147 bp + 2661 bp + 7284 bp.)
Application Data
(Schematic representation of pLenti-AAVR-Puro Vector (11092 bp, Ampicillin-resistant). EcoRI Digestion: 1147 bp + 2661 bp + 7284 bp.)
Application Data
(Schematic representation of the domain structure of AAVR)
Application Data
(Schematic representation of the domain structure of AAVR)
Related Product Information for pLenti-AAVR-Puro vector
Adeno-associated viruses (AAVs) are derived from defective parvoviruses, which depend on essential helper functions provided by other viruses, such as adenovirus and herpes virus, for efficient viral replication and propagation. AAV has no etiologic association with any known diseases and has been successfully used to establish efficient and long-term gene expression in vivo in a variety of tissues without significant cellular immune responses or toxicity. AAV has a single-stranded DNA genome which consists of approximately 4.7 kb. All characterized AAV serotypes share three key features, including two copies of AAV terminal repeats (ITRs), one rep region and one cap region. Recently, through genome-wide screening for genes essential to AAV transduction, type I transmembrane protein, KIAA0319L (renamed as AAV receptor (AAVR)) was implicated as the key receptor for entry of a panel of AAV serotypes into representative cell types and, in vivo, in mice (Ref. 4). AAVR has a single transmembrane region and a short C-terminal cytoplasmic domain required for retrograde trafficking to the trans-Golgi network. Its ectodomain, which binds AAV’s capsid, comprises five tandem Ig-like PKD (polycystic kidney disease) domains, a MANEC domain, and an N-terminal signal peptide (Figure 1).
Product Categories/Family for pLenti-AAVR-Puro vector
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Product Notes
The pLenti-AAVR-Puro (Catalog #AAA44710) is a Vector and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "pLenti-AAVR-Puro, Vector" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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