DR3/TNFRSF25 active protein

Recombinant human DR3/TNFRSF25 protein

Cat. Num. AAA48394

• Gene Names: TNFRSF25; DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12
• Applications: SDS-Page
• Purity: >95% by SDS-PAGE
• Synonyms: DR3/TNFRSF25; N/A; Recombinant human DR3/TNFRSF25 protein; Tumor necrosis factor receptor superfamily member 25; TNFRSF25; APO-3; DDR3; DR3; LARD; TNFRSF12; TRAMP; Apo-3; Apo3; Apoptosis inducing receptor AIR; Apoptosis mediating receptor DR 3; Death domain receptor 3; Death receptor 3; Lymphocyte associated receptor of death; Protein WSL; Protein WSL-1; Tumor necrosis factor receptor superfamily member 25 isoform 2; DR3/TNFRSF25 active protein

• Host: Baculovirus
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid. In Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
• Concentration: 0.25mg/ml (determined by absorbance at 280nm) (varies by lot)
• Sequence Positions: 25-199aa
• Sequence: QGGTRSP RCDCAGDFHK KIGLFCCRGC PAGHYLKAPC TEPCGNSTCL VCPQDTFLAW ENHHNSECAR CQACDEQASQ VALENCSAVA DTRCGCKPGW FVECQVSQCV SSSPFYCQPC LDCGALHRHT RLLCSRRDTD CGTCLPGFYE HGDGCVSCPT STLGSCPERC AAVCGWRQ

• Applicable Applications for DR3/TNFRSF25 active protein: Bioactivity, SDS-PAGE
• Endotoxin: <1 EU per 1ug of protein (determined by LAL method)
• Species: Human
• Tag: hIgG-His-Tag
• Predicted N-term: Ala
• Bioactivity: Measured by its binding ability in a functional ELISA with Human TL1A/TNFSF15. The ED50 range <= 5ug/ml.
• Preparation and Storage: Can be stored at +2C to +8 degree C for 1 week. For long term storage, aliquot and store at -20C to -80 degree C. Avoid repeated freezing and thawing cycles.

Bioactivity

(Human TL1A/TNFSF15 (CAT# ATGP1049) is coated at 10 ug/ml (100 ul/well) can bind Human DR3/TNFRSF25. The ED50 range )

SDS-PAGE

(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)

Related Product Information for DR3/TNFRSF25 active protein

TNFRSF25, also known as Tumor necrosis factor receptor superfamily member 25, is a member of the TNF receptor superfamily that binds to the TNF-like protein TL1A. TNFRSF25 signals are required to exert T helper cell 2 effector function in Th2-polarized CD4 cells and co-stimulate interleukin-13 production by glycosphingolipidactivated NKT cells. Its axis is a novel immune pathway that participates in the pathogenesis of a variety of autoimmune rheumatic diseases. These molecules may be promising therapeutic targets for inflammatory arthritis. Recombinant human TNFRSF25, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for DR3/TNFRSF25 active protein

Apoptosis; Proteins

References

Slebioda TJ., et al. (2011) Eur J Immunol. 41:2606-2611. Fang L., et al. (2008) J Exp Medl. 205:1037-1048.

NCBI and Uniprot Product Information

• NCBI GI #: 4507569
• NCBI GeneID: 8718
• NCBI Accession #: NP_003781.1
• NCBI GenBank Nucleotide #: NM_003790.2
• UniProt Accession #: Q93038; O00275; O00276; O00277; O00278; O00279; O00280; O14865; O14866; B1ALX2; B1ALX3; B7ZLL7
• Molecular Weight: 29,111 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 25 isoform 2
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 25
• NCBI Official Symbol: TNFRSF25
• NCBI Official Synonym Symbols: DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 25; protein WSL-1; death receptor beta; apoptosis inducing receptor; apoptosis-inducing receptor AIR; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble f
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 25
• UniProt Gene Name: TNFRSF25
• UniProt Synonym Gene Names: APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; LARD
• UniProt Entry Name: TNR25_HUMAN