WB (Western Blot)
(Western blot analysis of extracts from Jurkat, using DR3 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit DR3 Polyclonal Antibody | anti-TNFRSF25 antibody
DR3 Antibody
Gene Names
TNFRSF25; DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; GEF720; WSL-LR; PLEKHG5; TNFRSF12
Reactivity
HumanPredicted Reactivity: Bovine(83%), Sheep(83%)
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
DR3, Antibody; DR3 Antibody; Apo 3; Apo-3; Apo3; Apoptosis inducing receptor AIR; Apoptosis inducing receptor; Apoptosis mediating receptor; Apoptosis mediating receptor DR 3; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; DDR 3; DDR3; Death domain receptor 3; Death domain receptor 3 soluble form; Death receptor 3; Death receptor beta; DR 3; DR3; LARD; Lymphocyte associated receptor of death; Lymphocyte-associated receptor of death; Protein WSL; Protein WSL-1; TNF receptor superfamily member 25; TNFR25; TNFRSF 12; TNFRSF 25; TNFRSF12; formerly; TNFRSF25; TNR25_HUMAN; TR 3; TR3; TRAMP; Translocating chain association membrane protein; Tumor necrosis factor receptor superfamily member 12; Tumor necrosis factor receptor superfamily member 25; Tumor necrosis factor receptor superfamily; member 12 (translocating chain association membrane protein); member 12; WSL 1; WSL; WSL LR; WSL protein; WSL1; WSL1 protein; WSLLR; anti-TNFRSF25 antibody
Host
Rabbit
Reactivity
Human
Predicted Reactivity: Bovine(83%), Sheep(83%)
Predicted Reactivity: Bovine(83%), Sheep(83%)
Clonality
Polyclonal
Isotype
IgG
Specificity
DR3 Antibody detects endogenous levels of total DR3.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1mg/ml (varies by lot)
Sequence Length
372
Applicable Applications for anti-TNFRSF25 antibody
ELISA
Immunogen
A synthesized peptide derived from human DR3, corresponding to a region within the internal amino acids.
Fragment
Fab fragment
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
WB (Western Blot)
(Western blot analysis of extracts from Jurkat, using DR3 Antibody. The lane on the left was treated with blocking peptide.)
WB (Western Blot)
(Western blot analysis of extracts from Jurkat, using DR3 Antibody. The lane on the left was treated with blocking peptide.)
WB (Western Blot)
(Western blot analysis of extracts from Hela cells, using DR3 Antibody. The lane on the left was treated with blocking peptide.)
WB (Western Blot)
(Western blot analysis of extracts from Hela cells, using DR3 Antibody. The lane on the left was treated with blocking peptide.)
Related Product Information for anti-TNFRSF25 antibody
Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Post Translational Modifications: Glycosylated.
Subcellular Location: Cell membrane>Single-pass type I membrane protein. Cell membrane>Single-pass type I membrane protein. Cell membrane>Single-pass type I membrane protein. Cell membrane>Single-pass type I membrane protein. Secreted. Secreted. Secreted. Secreted. Secreted. Secreted. Secreted. Secreted.
Tissue Specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
Subunit Structure: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.
Post Translational Modifications: Glycosylated.
Subcellular Location: Cell membrane>Single-pass type I membrane protein. Cell membrane>Single-pass type I membrane protein. Cell membrane>Single-pass type I membrane protein. Cell membrane>Single-pass type I membrane protein. Secreted. Secreted. Secreted. Secreted. Secreted. Secreted. Secreted. Secreted.
Tissue Specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
Subunit Structure: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Observed Molecular Weight: (Observed)45kD.
Predicted Molecular Weight: (Calculated)45kDa.
Predicted Molecular Weight: (Calculated)45kDa.
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 25 isoform 4
NCBI Official Synonym Full Names
TNF receptor superfamily member 25
NCBI Official Symbol
TNFRSF25
NCBI Official Synonym Symbols
DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; GEF720; WSL-LR; PLEKHG5; TNFRSF12
NCBI Protein Information
tumor necrosis factor receptor superfamily member 25
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 25
UniProt Gene Name
TNFRSF25
UniProt Synonym Gene Names
APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; LARD
UniProt Entry Name
TNR25_HUMAN
Similar Products
Product Notes
The TNFRSF25 tnfrsf25 (Catalog #AAA329039) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DR3 Antibody reacts with Human Predicted Reactivity: Bovine(83%), Sheep(83%) and may cross-react with other species as described in the data sheet. AAA Biotech's DR3 can be used in a range of immunoassay formats including, but not limited to, ELISA. Researchers should empirically determine the suitability of the TNFRSF25 tnfrsf25 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.