Structure
(Mal-PFP ester, CAS 138194-55-5)
Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt) Biochemical
Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt)
Purity
98%
Synonyms
Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt); N/A; Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt) biochemical
Purity/Purification
98%
Solubility
DMF: 30 mg/mL
Ethanol: 10 mg/mL
DMSO: 30 mg/mL
PBS (pH 7.2): 2.5 mg/mL
<1mg/ml refers to the product slightly soluble or insoluble
Ethanol: 10 mg/mL
DMSO: 30 mg/mL
PBS (pH 7.2): 2.5 mg/mL
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Mal-PFP ester, CAS 138194-55-5)
Structure
(Mal-PFP ester, CAS 138194-55-5)
Structure
(Mal-PFP ester, CAS 138194-55-5)
Structure
(Mal-PFP ester, CAS 138194-55-5)
Related Product Information for Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt) biochemical
Enteropeptidase fluorogenic substrate is a substrate for enteropeptidase that contains a 7-amino-4-trifluoromethylcoumarin (AFC) moiety. Enteropeptidase is a serine protease expressed in the proximal small intestine of higher animals that converts inactive trypsinogen to active trypsin by endoproteolytic cleavage.1,2Enteropeptidase recognizes the highly specific amino acid sequence DDDDK on the fluorogenic substrate and cleaves after the lysine residue, releasing the AFC moiety. Enteropeptidase activity is quantified by fluorescent detection of AFC, which displays excitation/emission spectra of 380/500 nm.3
References
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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Product Notes
The Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt) (Catalog #AAA227252) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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