Structure
(PRMT5-IN-14, CAS 2278356-90-2)
MW-150 hydrochloride Biochemical | MW-150 biochemical
MW-150 hydrochloride
Purity
98%
Synonyms
MW-150 hydrochloride; N/A; MW-150 biochemical
Purity/Purification
98%
CAS
1923773-01-6
Targets&IC50
p38alpha:101 nM (Ki)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
MW-150 hydrochloride (MW01-18-150SRM hydrochloride)(2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1]. MW-150 hydrochloride (MW01-18-150SRM hydrochloride)(2.5 mg/kg; given i.p.; daily for 14 days) treatment in APP NLh/NLh × PS P264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1]. Animal Model: APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta)[1]. Dosage: 2.5 mg/kg. Administration: Oral daily; 3-4 months (until cognitive impairment is present). Result: Improved the Tg mice performance in both cognitive tests.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(PRMT5-IN-14, CAS 2278356-90-2)
Structure
(PRMT5-IN-14, CAS 2278356-90-2)
Structure
(PRMT5-IN-14, CAS 2278356-90-2)
Structure
(PRMT5-IN-14, CAS 2278356-90-2)
Related Product Information for MW-150 biochemical
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor of p38alpha MAPK with a K i of 101 nM. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits the ability of the endogenous p38alpha MAPK to phosphorylate an endogenous substrate MK2 in activated glia.
References
1. Machacek M, et al. Prmt5 inhibitors. WO2020033285A1.
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Product Notes
The MW-150 (Catalog #AAA227986) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MW-150 hydrochloride, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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