PTTG1 blocking peptide
PTTG1 Antibody (N-term) Blocking Peptide
Gene Names
PTTG1; EAP1; PTTG; HPTTG; TUTR1
Synonyms
PTTG1; N/A; PTTG1 Antibody (N-term) Blocking Peptide; Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG; EAP1; PTTG; TUTR1; PTTG1 blocking peptide
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human PTTG1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
202
Cellular Location
Cytoplasm. Nucleus.
Clone Names
80917167
Peptide ID
80917167
Tissue Location
Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for PTTG1 blocking peptide
PTTG1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The protein has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. This protein contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
Securin
NCBI Official Synonym Full Names
pituitary tumor-transforming 1
NCBI Official Symbol
PTTG1
NCBI Official Synonym Symbols
EAP1; PTTG; HPTTG; TUTR1
NCBI Protein Information
securin
UniProt Protein Name
Securin
UniProt Gene Name
PTTG1
UniProt Synonym Gene Names
EAP1; PTTG; TUTR1; Tumor-transforming protein 1; hPTTG
UniProt Entry Name
PTTG1_HUMAN
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Product Notes
The PTTG1 pttg1 (Catalog #AAA290808) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PTTG1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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