mDia Phospho-Regulation Antibody Sampler Kit | mDia antibody sampler kit
mDia Phospho-Regulation
Reactivity
Human, Rat, Mouse, Fish
Applications
ELISA, Western Blot
Synonyms
mDia Phospho-Regulation; N/A; mDia antibody sampler kit
Reactivity
Human, Rat, Mouse, Fish
Form/Format
Rabbit polyclonal, affinity-purified antibodies are supplied in phosphate-buffered saline, 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide.
Applicable Applications for mDia antibody sampler kit
ELISA, WB (Western Blot)
Preparation and Storage
Store at -20 degree C. Stable for 1 year.
Related Product Information for mDia antibody sampler kit
Background: Formins include several families of proteins that regulate actin cytoskeletal dynamics via two conserved formin homology domains, FH1 and FH2. Formins construct actin-based structures comprising linear, unbranched filaments that are used in stress fibers, actin cables, microspikes, and contractile rings. The diaphanous (Dia) formin subfamily includes mDia1 (Diap1), mDia2 (Diap3), and mDia3 (Diap2). mDia1 protein is activated by Rho leading to ROCK-dependent stress fiber formation and regulation of serum response factor-dependent transcription. mDia2 is activated by Rac or Cdc42, and it nucleates actin polymerization and stabilizes microtubules. Regulation of mDia2 activity may occur through ROCK phosphorylation of Thr-1061 and Ser-1070. mDia3 is activated by Cdc42 and regulates the attachment of microtubules to the kinetochore during mitosis. Aurora B kinase phosphorylates Ser-196 and Thr-882 in vitro, and phosphorylation of Ser -196 increases during mitosis in vivo.
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Product Notes
The Human, Rat, Mouse, Fish mDia (Catalog #AAA71616) is an Antibody Sampler Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA71616 Antibody Sampler Kit recognizes Human, Rat, Mouse, Fish mDia. AAA Biotech's mDia Phospho-Regulation can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the mDia for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "mDia Phospho-Regulation, Antibody Sampler Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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