IL-2RG (CD132) Active Protein | IL2RG active protein

Human IL-2RG Recombinant (CD132)

Cat. Num. AAA14430

• Purity: >97%, as determined by SDS-PAGE
• Synonyms: IL-2RG (CD132); N/A; Human IL-2RG Recombinant (CD132); Human IL-2RG Recombinant; il-2RG; il2RG; CD132; IL2RG active protein

• Host: HEK Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
• Purity/Purification: >97%, as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered PBS solution pH 7.4.
• Sequence: LNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAHHHHHHHHHHH

• Host Note: DNA sequence encoding extracellular domain of Human IL2RG (Common gamma chain) to a C-terminal polyHis tag was expressed in HEK cells.
• Endotoxin: Endotoxin content was assayed using a LAL gel clot method.; Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Molecular Weight Note: Recombinant Human Interleukin-2 receptor gamma (Common gamma chain) is a monomer consisting of 242 amino acid residue, and migrates as an approximately 43 kDa protein under reducing conditions in SDS-PAGE.
• Biological Activity: The activity was determined by the ability to bind recombinant IL-2 in functional ELISA.
• Preparation and Storage: The lyophilized protein is stable for at least 1 year from date of receipt at -20°C.; Upon reconstitution, this cytokine can be stored in working aliquots at 2-8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.; ; Avoid repeated freeze/thaw cycles.

SDS-PAGE

Related Product Information for IL2RG active protein

Interleukin (IL) -2, IL-4, IL-7, IL-9 and IL-15 belong to a family of cytokines whose receptors share the common γ chain (γc). Despite some redundancy, these cytokines that signal through the γc (γccytokines) have essentially distinct and often critical effects in normal T-cell development, survival, proliferation and differentiation. Importantly, they have also been implicated, directly or indirectly, in T-cell leukemogenesis.

Product Categories/Family for IL2RG active protein

Receptors CD

References

• il-21 is the primary Common gamma chain-binding cytokine required for human b-cell differentiation in vivo .Blood, Oct 2011; 10.1182/blood-2011-06-362533.
• il-2r common -chain is epigenetically silenced by nucleophosphin–anaplastic lymphoma kinase (npm-alk) and acts as a tumor suppressor by targeting npm-alk .PNAS, Jul 2011; 108: 11977 - 11982.
• a subpopulation of follicular lymphoma tumor infiltrating t cells shows suppressed Common gamma chain cytokine signaling. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 759.
• common -chain-dependent signals confer selective survival of eosinophils in the murine small intestine .J. Immunol., Nov 2009; 183: 5600 - 5607.
• cell cycle progression following naive t cell activation is independent of jak3/common -chain cytokine signals .J. Immunol., Oct 2009; 183: 4493 - 4501.