Application Data
(Measured by its ability to induce apoptosis of TF1 human erythroleukemic cells.The ED50 for this effect is typically 20-120 ng/mL.)
TL1A Active Protein | TNFSF15 active protein
TL1A Protein, Human, Recombinant (rFc Tag)
Gene Names
TNFSF15; TL1; TL1A; VEGI; VEGI192A
Purity
>90% as determined by SDS-PAGE
Synonyms
TL1A; N/A; TL1A Protein, Human, Recombinant (rFc Tag); Human TL1A/TNFSF15 Protein (rFc Tag); TL1 Protein, Human; TL1A Protein, Human; VEGI Protein, Human; VEGI192A Protein, Human; tumor necrosis factor (ligand) superfamily, member 15; TNFSF15 active protein
Host
HEK293 Cells
Purity/Purification
>90% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Leu72-Leu251
Species
Human
Activity
Measured by its ability to induce apoptosis of TF1 human erythroleukemic cells. The ED50for this effect is typically 20-120ng/mL.
Endotoxin
<1.0EU per ug protein as determined by the LAL method.
Predicted N Terminal
Ser
Tag
N-rabbit IgG-Fc
Protein Construction
A DNA sequence encoding the human TNFSF15 (NP_005109.2)(Leu72-Leu251) was expressed with the Fc region of rabbit IgG at the N-terminus..
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
Application Data
(Measured by its ability to induce apoptosis of TF1 human erythroleukemic cells.The ED50 for this effect is typically 20-120 ng/mL.)
Application Data
(Measured by its ability to induce apoptosis of TF1 human erythroleukemic cells.The ED50 for this effect is typically 20-120 ng/mL.)
SDS-PAGE
SDS-PAGE
Related Product Information for TNFSF15 active protein
Background: TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.
Product Categories/Family for TNFSF15 active protein
References
Jin T, et al. (2007) X-ray crystal structure of TNF ligand family member TL1A at 2.1A. Biochem Biophys Res Commun. 364(1):1-6.Cassatella MA, et al. (2007) Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis. J Immunol. 178(11):7325-33Prehn JL, et al. (2007) The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. J Immunol. 178(7):4033-8.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
20,131 Da
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 15 isoform VEGI-251
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 15
NCBI Official Symbol
TNFSF15
NCBI Official Synonym Symbols
TL1; TL1A; VEGI; VEGI192A
NCBI Protein Information
tumor necrosis factor ligand superfamily member 15; TNF superfamily ligand TL1A; TNF ligand-related molecule 1; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor-192A
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 15
UniProt Gene Name
TNFSF15
UniProt Synonym Gene Names
TL1; VEGI
UniProt Entry Name
TNF15_HUMAN
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Product Notes
The TNFSF15 tnfsf15 (Catalog #AAA258057) is an Active Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Leu72-Leu2 51. It is sometimes possible for the material contained within the vial of "TL1A, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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