GFR alpha-1 Active Protein | GFRalpha-1 active protein

Recombinant human GFR alpha-1 protein

Cat. Num. AAA49003

• Gene Names: GFRA1; GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: GFR alpha-1; N/A; Recombinant human GFR alpha-1 protein; GDNF family receptor alpha-1 isoform b; GDNF receptor alpha-1; GDNF R alpha-1; GFR alpha1; GFR-ALPHA-1; GFRa-1; GFRalpha-1; GFRA1; GDNFR; GDNFRA; RET1L; RETL1; TRNR1; RHDA4; RET ligand; TGF-beta-related neurotrophic factor receptor 1; GFRalpha-1 active protein

• Host: HEK293
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid in. Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
• Concentration: 0.5 mg/ml (determined by absorbance at 280nm) (varies by lot)
• Sequence Positions: 25-424aa
• Sequence: Asp 25; DRLDCVKASD QCLKEQSCST KYRTLRQCVA GKETNFSLAS GLEAKDECRS AMEALKQKSL YNCRCKRGMK KEKNCLRIYW SMYQSLQGND LLEDSPYEPV NSRLSDIFRV VPFISVEHIP KGNNCLDAAK ACNLDDICKK YRSAYITPCT TSVSNDVCNR RKCHKALRQF FDKVPAKHSY GMLFCSCRDI ACTERRRQTI VPVCSYEERE KPNCLNLQDS CKTNYICRSR LADFFTNCQP ESRSVSSCLK ENYADCLLAY SGLIGTVMTP NYIDSSSLSV APWCDCSNSG NDLEECLKFL NFFKDNTCLK NAIQAFGNGS DVTVWQPAFP VQTTTATTTT ALRVKNKPLG PAGSENEIPT HVLPPCANLQ AQKLKSNVSG NTHLCISNGN YEKEGLGASS

• Applicable Applications for GFRalpha-1 active protein: Bioactivity, SDS-PAGE
• Species: Human
• Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
• Tag: hIgG-Tag
• Preparation and Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Related Product Information for GFRalpha-1 active protein

GFR alpha-1, also known as GDNF family receptor alpha-1, belongs to the GDNFR family. It is a glycosylphosphatidylinositol (GPI)-linked receptor found on the cell surface, acting as a receptor for both GDNF and NTN and function as neurotrophic factors for a variety of neuronal populations in the central and peripheral nervous systems. It bind GDNF strongly and activate RET tyrosine kinase and is also essential for the development of kidneys and the enteric nervous system. Recombinant human GFR alpha-1, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Categories/Family for GFRalpha-1 active protein

Neuroscience; Proteins

References

Thompson, J. et al. (1998) Mol. Cell Neurosci. 11:117-126.
Baloh, R.H. et al. (1998) Proc. Natl. Acad. Sci. USA 95:5801-5806.
Jing S, et al. (1996). Cell. 85:1113-1124.
Treanor JJ, et al. (1996). 382: 80-83.
Jing S, et al. (1997). J Biol Chem. 272: 33111-33117.

NCBI and Uniprot Product Information

• NCBI GI #: 22035692
• NCBI GeneID: 2674
• NCBI Accession #: NP_665736.1
• NCBI GenBank Nucleotide #: NM_145793.3
• UniProt Accession #: P56159; O15507; O43912; A8KA21
• Molecular Weight: 51,456 Da
• NCBI Official Full Name: GDNF family receptor alpha-1 isoform b preproprotein
• NCBI Official Synonym Full Names: GDNF family receptor alpha 1
• NCBI Official Symbol: GFRA1
• NCBI Official Synonym Symbols: GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
• NCBI Protein Information: GDNF family receptor alpha-1; RET ligand 1; GDNFR-alpha-1; GDNF receptor alpha-1; GPI-linked anchor protein; PI-linked cell-surface accessory protein; TGF-beta related neurotrophic factor receptor 1; TGF-beta-related neurotrophic factor receptor 1; Glial
• UniProt Protein Name: GDNF family receptor alpha-1
• UniProt Gene Name: GFRA1
• UniProt Synonym Gene Names: GDNFRA; RETL1; TRNR1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1
• UniProt Entry Name: GFRA1_HUMAN