SDS-PAGE
ICOS / AILIM / CD278 active protein
Recombinant Human ICOS / AILIM / CD278 Protein (His & Fc tag)
Gene Names
ICOS; AILIM; CD278; CVID1
Purity
>90% as determined by SDS-PAGE
Synonyms
ICOS / AILIM / CD278; N/A; Recombinant Human ICOS / AILIM / CD278 Protein (His & Fc tag); AILIM, CD278, CVID1; ICOS / AILIM / CD278 active protein
Host
Human Cells
Purity/Purification
>90% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile 20 mM Tris, 150mM NaCI, pH 8.5, 5% Trehalose 5% mannitol, 0.01% Tween-80
Sequence Length
199
Source
Human
Predicted N Terminal
Glu 21
Reconstitution
It is recommended that sterile water (400 uL) be added to the vial to prepare a stock solution of 0.25 mg/mL/.
Concentration is measured by UV-Vis.
Concentration is measured by UV-Vis.
Endotoxin
< 1.0 EU per ug of the protein as determined by the LAL method
Bio-Activity
Measured by its binding ability in a functional ELISA. Inmobilized human B7-H2 at 1 ug/mL/ (100 uL/ well.) can bind human ICOS with a linear range of 1.6-200- ng/mL.
Preparation and Storage
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
SDS-PAGE
SDS-PAGE
Related Product Information for ICOS / AILIM / CD278 active protein
Background: Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T-B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.
Description: A DNA sequence encoding the extracellular domain of human ICOS (NP_036224.1) (Met 1-Phe 141) was fused to the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the extracellular domain of human ICOS (NP_036224.1) (Met 1-Phe 141) was fused to the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
inducible T-cell costimulator
NCBI Official Synonym Full Names
inducible T-cell costimulator
NCBI Official Symbol
ICOS
NCBI Official Synonym Symbols
AILIM; CD278; CVID1
NCBI Protein Information
inducible T-cell costimulator
UniProt Protein Name
Inducible T-cell costimulator
UniProt Gene Name
ICOS
UniProt Synonym Gene Names
AILIM
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Product Notes
The ICOS / AILIM / CD278 icos (Catalog #AAA173569) is an Active Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ICOS / AILIM / CD278, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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