Human Prolactin Receptor, PRLR ELISA Kit | PRLR elisa kit

Human Prolactin Receptor, PRLR Primacu ELISA Kit

Cat. Num. AAA124387

• Gene Names: PRLR; hPRLrI
• Reactivity: Human
• Synonyms: Prolactin Receptor, PRLR; N/A; Human Prolactin Receptor, PRLR Primacu ELISA Kit; Prolactin receptor; Prolactin Receptor; PRLR elisa kit

• Reactivity: Human
• Assay Type: Sandwich
• Samples: Serum, plasma, cell culture supernates
• Detection Range: 7.81-500pg/mL
• Sensitivity: 1.64pg/mL
• Standard Solution: 5ng/mL
• Assay Time: 3.5h

• Preparation and Storage: Store at 2-8 degree C

Standard Curve (Sample)

(Typical Testing Data/Standard Curve (for reference only))

Related Product Information for PRLR elisa kit

Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-I¢ domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules involved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer.

Product Categories/Family for PRLR elisa kit

Primacu ELISA Kit; Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4506107
• NCBI GeneID: 5618
• NCBI Accession #: NP_000940.1
• NCBI GenBank Nucleotide #: NM_000949.5
• UniProt Accession #: P16471; Q16354; Q8TD75; Q8TD78; Q96P35; Q96P36; Q9BX87; Q9UHJ5; B2R882
• Molecular Weight: 24,000
• NCBI Official Full Name: prolactin receptor isoform 1
• NCBI Official Synonym Full Names: prolactin receptor
• NCBI Official Symbol: PRLR
• NCBI Official Synonym Symbols: hPRLrI
• NCBI Protein Information: prolactin receptor; PRL-R; hPRL receptor; secreted prolactin binding protein
• UniProt Protein Name: Prolactin receptor
• UniProt Gene Name: PRLR
• UniProt Synonym Gene Names: PRL-R
• UniProt Entry Name: PRLR_HUMAN