Standard Curve (Sample)
Human Runt-Related Transcription Factor 3 (RUNX3) ELISA Kit | RUNX3 elisa kit
Human Runt-Related Transcription Factor 3 (RUNX3) ELISA Kit
Gene Names
RUNX3; AML2; CBFA3; PEBP2aC
Reactivity
Human
Synonyms
Runt-Related Transcription Factor 3 (RUNX3); N/A; Human Runt-Related Transcription Factor 3 (RUNX3) ELISA Kit; RUNX3; RP3-398I9.1; AML2; CBFA3; FLJ34510; MGC16070; PEBP2aC; OTTHUMP00000003371; PEA2 alpha C; PEBP2 alpha C; acute myeloid leukemia gene 2; core-binding factor; runt domain; alpha subunit 3; polyomavirus enha; RUNX3 elisa kit
Reactivity
Human
Sequence Length
429
Assay Type
Sandwich
Preparation and Storage
Store at 2-8 degree C.
Standard Curve (Sample)
Standard Curve (Sample)
Related Product Information for RUNX3 elisa kit
Principle of the Assay: Human Runt-related Transcription Factor 3 (RUNX3) ELISA Kit employs a two-site sandwich ELISA to quantitate RUNX3 in samples. An antibody specific for RUNX3 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any RUNX3 present is bound by the immobilized antibody. After removing any unbound substances, HRP-Conjugated Human RUNX3 detection antibody is added to the wells. Following a wash to remove any unbound HRP reagent, a Chromogen solution is added to the wells and color develops in proportion to the amount of RUNX3 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Background/Introduction: RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta stimulation.
Background/Introduction: RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta stimulation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
runt-related transcription factor 3 isoform 1
NCBI Official Synonym Full Names
RUNX family transcription factor 3
NCBI Official Symbol
RUNX3
NCBI Official Synonym Symbols
AML2; CBFA3; PEBP2aC
NCBI Protein Information
runt-related transcription factor 3
UniProt Protein Name
Runt-related transcription factor 3
UniProt Gene Name
RUNX3
UniProt Synonym Gene Names
AML2; CBFA3; PEBP2A3; CBF-alpha-3; PEA2-alpha C
UniProt Entry Name
RUNX3_HUMAN
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Product Notes
The Human RUNX3 runx3 (Catalog #AAA330977) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA330977 ELISA Kit recognizes Human RUNX3. It is sometimes possible for the material contained within the vial of "Runt-Related Transcription Factor 3 (RUNX3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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