IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Anaplastic Large Cell Lymphoma stained with ALK1 Recombinant Rabbit Monoclonal Antibody (ALK1/7008R).)
Rabbit anti-Human ALK (Anaplastic Lymphoma Kinase)/CD246 Monoclonal Antibody | anti-ALK antibody
ALK (Anaplastic Lymphoma Kinase)/CD246 Recombinant Rabbit Monoclonal Antibody [Clone ALK1/7008R]
Gene Names
ALK; CD246; NBLST3
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
ALK (Anaplastic Lymphoma Kinase)/CD246, Antibody; ALK (Anaplastic Lymphoma Kinase)/CD246 Recombinant Rabbit Monoclonal Antibody [Clone ALK1/7008R]; ALK Tyrosine Kinase Receptor, ALK/NPM1 fusion gene, Anaplastic lymphoma kinase Ki1, Anaplastic Lymphoma Kinase p80, anaplastic lymphoma receptor tyrosine kinase, CD246, mutant anaplastic lymphoma kinase, NBLST3, Tcrz, TFG/ALK; anti-ALK antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit/IgG, kappa
Clone Number
ALK1/7008R
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
Applicable Applications for anti-ALK antibody
IHC (Immunohistochemistry)
Antibody Type
Recombinant Antibody
Immunogen
Recombinant human ALK protein fragment corresponding to the cytoplasmic domain
Cellular Localization
Cytoplasm, Nuclear
Positive Control
Human Anaplastic Large Cell Lymphoma (ALCL) tissue.
Hu-chromosome Location
2p23
Unigene
654469
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Anaplastic Large Cell Lymphoma stained with ALK1 Recombinant Rabbit Monoclonal Antibody (ALK1/7008R).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Anaplastic Large Cell Lymphoma stained with ALK1 Recombinant Rabbit Monoclonal Antibody (ALK1/7008R).)
Related Product Information for anti-ALK antibody
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase of the insulin receptor superfamily. ALK is typically expressed at low levels in regions of the developing central and peripheral nervous system. ALK may be activated in cancer through multiple mechanisms. The most common mechanism is through formation of a fusion protein from chromosomal translocations, as in the case of anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumors. ALK may also be amplified through mutation, as in neuroblastomas. Various solid tumors, such as non-small cell lung carcinoma (NSCLC) and brain cancers were also found to aberrantly express ALK. ALK staining is present within both the nucleus and cytoplasm, and are positive in about 60% of ALCL. ALK protein expression by tumor cells is an independent prognostic factor that predicts a favorable outcome.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
176,442 Da
NCBI Official Full Name
ALK tyrosine kinase receptor
NCBI Official Synonym Full Names
anaplastic lymphoma receptor tyrosine kinase
NCBI Official Symbol
ALK
NCBI Official Synonym Symbols
CD246; NBLST3
NCBI Protein Information
ALK tyrosine kinase receptor; CD246 antigen; mutant anaplastic lymphoma kinase
UniProt Protein Name
ALK tyrosine kinase receptor
UniProt Gene Name
ALK
UniProt Entry Name
ALK_HUMAN
Similar Products
Product Notes
The ALK alk (Catalog #AAA215663) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ALK (Anaplastic Lymphoma Kinase)/CD246 Recombinant Rabbit Monoclonal Antibody [Clone ALK1/7008R] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ALK (Anaplastic Lymphoma Kinase)/CD246 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the ALK alk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ALK (Anaplastic Lymphoma Kinase)/CD246, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.