Mouse anti-Human beta Amyloid Monoclonal Antibody | anti-APP antibody

beta Amyloid Mouse Monoclonal Antibody [Clone APP/3345]

Cat. Num. AAA215732

• Gene Names: APP; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma
• Reactivity: Human
• Applications: Immunohistochemistry, Flow Cytometry, Functional Assay, Immunofluorescence
• Synonyms: beta Amyloid, Antibody; beta Amyloid Mouse Monoclonal Antibody [Clone APP/3345]; CVAP; AAA; AICD-50; PN2; 50; Beta-APP42; AID; S-APP-alpha; 57; AD1; PN-II; Beta-APP40; 42; 40; APPI; Alzheimer disease amyloid protein; PreA4; ABETA; Amyloid intracellular domain 50; 59 AICD-59; S-APP-beta; APP; AICD-57; ABPP; Protease nexin-II; Cerebral vascular amyloid peptide; anti-APP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse/IgG2c, kappa
• Clone Number: APP/3345
• Form/Format: 200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA at 1.0mg/ml.
• Concentration: Purified Ab with BSA and Azide at 200ug/ml; OR; Purified Ab WITHOUT BSA at 1.0mg/ml (varies by lot)

• Applicable Applications for anti-APP antibody: IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry), IF (Immunofluorescence)
• Immunogen: Recombinant fragment (around aa578-680) of human Amyloid Beta protein (exact sequence is proprietary)
• Cellular Localization: Membrane, Membrane > clathrin-coated pit. Cell surface protein that rapidly becomes internalized via clathrin-coated pits
• Positive Control: Alzheimer's disease brain. Amyloidosis.
• Hu-chromosome Location: 21q21.3
• Unigene: 434980
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C; Antibody without azide: store at -20 to -80 degree C; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified Beta Amyloid Mouse Monoclonal Antibody (APP/3345). Confirmation of Purity and Integrity of Antibody.)

Related Product Information for anti-APP antibody

Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the beta-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the 4 kDa Amyloid beta/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

NCBI and Uniprot Product Information

• NCBI GI #: 4502167
• NCBI GeneID: 351
• NCBI Accession #: NP_000475.1
• NCBI GenBank Nucleotide #: NM_000484.3
• UniProt Accession #: P05067; P09000; P78438; Q13764; Q13778; Q13793; Q16011; B2R5V1; B4DII8; D3DSD1; D3DSD2; D3DSD3
• Molecular Weight: 86,943 Da
• NCBI Official Full Name: amyloid beta A4 protein isoform a
• NCBI Official Synonym Full Names: amyloid beta (A4) precursor protein
• NCBI Official Symbol: APP
• NCBI Official Synonym Symbols: AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma
• NCBI Protein Information: amyloid beta A4 protein; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide
• UniProt Protein Name: Amyloid beta A4 protein
• UniProt Gene Name: APP
• UniProt Synonym Gene Names: A4; AD1; APP; CVAP; PN-II; S-APP-alpha; S-APP-beta; AICD-59; AID(59); AICD-57; AID(57); AICD-50; AID(50)
• UniProt Entry Name: A4_HUMAN