WB (Western Blot)
(Western blot analysis of CBL in Hela lysates using CBL antibody.)
Rabbit anti-Human CBL Monoclonal Antibody | anti-CBL antibody
CBL Rabbit mAb
Gene Names
CBL; CBL2; NSLL; C-CBL; RNF55; FRA11B
Reactivity
Human
Applications
Immunoprecipitation, Immunofluorescence, Immunocytochemistry, Western Blot
Purity
Affinity Purified
Synonyms
CBL, Antibody; CBL Rabbit mAb; CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL; anti-CBL antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
R01-9G1
Purity/Purification
Affinity Purified
Form/Format
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Applicable Applications for anti-CBL antibody
IP (Immunoprecipitation), IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot)
Immunogen
A synthetic peptide of human CBL
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycles.
WB (Western Blot)
(Western blot analysis of CBL in Hela lysates using CBL antibody.)
WB (Western Blot)
(Western blot analysis of CBL in Hela lysates using CBL antibody.)
ICC (Immunocytochemistry)
(Immunocytochemistry analysis of CBL (green) in K562 using CBL antibody,and DAPI(blue).)
ICC (Immunocytochemistry)
(Immunocytochemistry analysis of CBL (green) in K562 using CBL antibody,and DAPI(blue).)
Related Product Information for anti-CBL antibody
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder
Product Categories/Family for anti-CBL antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
99,633 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase CBL
NCBI Official Synonym Full Names
Cbl proto-oncogene, E3 ubiquitin protein ligase
NCBI Official Symbol
CBL
NCBI Official Synonym Symbols
CBL2; NSLL; C-CBL; RNF55; FRA11B
NCBI Protein Information
E3 ubiquitin-protein ligase CBL; oncogene CBL2; proto-oncogene c-Cbl; RING finger protein 55; signal transduction protein CBL; casitas B-lineage lymphoma proto-oncogene; fragile site, folic acid type, rare, fra(11)(q23.3); Cas-Br-M (murine) ecotropic retr
UniProt Protein Name
E3 ubiquitin-protein ligase CBL
UniProt Gene Name
CBL
UniProt Synonym Gene Names
CBL2; RNF55
UniProt Entry Name
CBL_HUMAN
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Product Notes
The CBL cbl (Catalog #AAA269300) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CBL Rabbit mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CBL can be used in a range of immunoassay formats including, but not limited to, IP (Immunoprecipitation), IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the CBL cbl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CBL, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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