Mouse anti-Human. CD11c Monoclonal Antibody | anti-ITGAX antibody
CD11c
Gene Names
ITGAX; CD11C; SLEB6
Reactivity
Human.
Applications
Immunohistochemistry, Immunoprecipitation, Functional Assay, Immunofluorescence, Flow Cytometry, Functional Assay, ELISA
Synonyms
CD11c, Antibody; CD11c; CD11 antigen-like family member C; Complement component 3 receptor 4 subunit; Integrin alpha-X; integrin; alpha X (antigen CD11C (p150); alpha polypeptide); Leu M5 alpha subunit; Leukocyte adhesion glycoprotein p150 95 alpha chain; Myeloid membrane antigen alpha subunit; p150/95; anti-ITGAX antibody
Host
Mouse
Reactivity
Human.
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
HC1/1
Specificity
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute non-lymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
1163
Applicable Applications for anti-ITGAX antibody
IHC (Immunohistochemistry), IP (Immunoprecipitation), FA (Functional Assay), IF (Immunofluorescence), FCM/FACS (Flow Cytometry), ELISA
Localization
Cell surface
Positive Control
Human dendritic cells. Human lymph nodes and tonsils.
Human Chromosomal Location
16p11.2
Immunogen
Human monocytic U937 phorbol ester-treated cells
Quantity and Buffer
0.5 ml at 200ug/ml with BSA and azide
Preparation and Storage
Store at 2 to 8 degree C. Antibody is stable for 24 months.
References
1. Nicolaou, F., et al. 2003. CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes Ras and JunD. Blood 101: 4033-4041.
2. Edwards, A.D., et al. 2003. Relationships among murine CD11c (high) dendritic cell subsets as revealed by baseline gene expression patterns. J. Immunol. 171: 47-60.
2. Edwards, A.D., et al. 2003. Relationships among murine CD11c (high) dendritic cell subsets as revealed by baseline gene expression patterns. J. Immunol. 171: 47-60.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
145kDa
NCBI Official Full Name
integrin alpha-X isoform 2
NCBI Official Synonym Full Names
integrin, alpha X (complement component 3 receptor 4 subunit)
NCBI Official Symbol
ITGAX
NCBI Official Synonym Symbols
CD11C; SLEB6
NCBI Protein Information
integrin alpha-X; leu M5, alpha subunit; p150 95 integrin alpha chain; CD11 antigen-like family member C; leukocyte adhesion receptor p150,95; myeloid membrane antigen, alpha subunit; leukocyte surface antigen p150,95, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
UniProt Protein Name
Integrin alpha-X
UniProt Gene Name
ITGAX
UniProt Synonym Gene Names
CD11C
UniProt Entry Name
ITAX_HUMAN
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Product Notes
The ITGAX itgax (Catalog #AAA62555) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD11c reacts with Human. and may cross-react with other species as described in the data sheet. AAA Biotech's CD11c can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IP (Immunoprecipitation), FA (Functional Assay), IF (Immunofluorescence), FCM/FACS (Flow Cytometry), ELISA. Researchers should empirically determine the suitability of the ITGAX itgax for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD11c, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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