Mouse anti-Human CD5 Monoclonal Antibody | anti-CD5 antibody

CD5 (Mantle Cell Lymphoma Marker) Recombinant Mouse Monoclonal Antibody [Clone rC5/6462]

Cat. Num. AAA216035

• Gene Names: CD5; T1; LEU1
• Reactivity: Human
• Applications: Immunohistochemistry
• Synonyms: CD5, Antibody; CD5 (Mantle Cell Lymphoma Marker) Recombinant Mouse Monoclonal Antibody [Clone rC5/6462]; CD5 (Mantle Cell Lymphoma Marker); CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5; anti-CD5 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse/IgG2a, kappa
• Clone Number: rC5/6462
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Concentration: Purified Ab with BSA and Azide at 200ug/ml; OR; Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)

• Applicable Applications for anti-CD5 antibody: IHC (Immunohistochemistry)
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant full-length protein corresponding to human CD5
• Cellular Localization: Cell Surface
• Positive Control: 293T, Ramos, or MOLT-4 cells. Human tonsil or lymph node.
• Hu-chromosome Location: 11q12.2
• Unigene: 58685
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C; Antibody without azide: store at -20 to -80 degree C; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human tonsil stained with CD5 Recombinant Mouse Monoclonal Antibody (rC5/6462).)

Related Product Information for anti-CD5 antibody

The CD5 antigen is a transmembrane glycoprotein expressed on the surface of practically all mature human T-cells (about 10% of CD4+ T-cells being CD5 negative). In immature (CD34+) T-cells, CD5 is weakly expressed, the intensity of expression increasing with maturation. CD5 is also expressed in a small subset of normal human B-cells (20% of B-cells in the peripheral blood, scattered cells in the lymph node mantle zone). The CD5+ cells are probably involved in B-T interaction and their ligand is CD72 which is expressed on all B cells. It appears that CD5+ B-cells on activation primarily produce IgM. They also produce more autoantibodies than normal CD5 negative B-cells. Thus, the CD5+ B-cell population is expanded in rheumatoid arthritis and systemic lupus erythematosus. The CD5 antibody reacts with CD5 expressed on B and T cells, and may be a useful aid for the classification of B and T-cell malignancies. This includes B-cell chronic lymphoid leukemia (B-CLL), B-cell small lymphocytic lymphoma (B-SLL), mantle cell lymphoma (MCL) and T-cell lymphoma and leukemia.

NCBI and Uniprot Product Information

• NCBI GI #: 166197668
• NCBI GeneID: 921
• NCBI Accession #: NP_055022.2
• NCBI GenBank Nucleotide #: NM_014207.3
• UniProt Accession #: P06127; A0N0P4; A8K9I3
• Molecular Weight: 54,578 Da
• NCBI Official Full Name: T-cell surface glycoprotein CD5
• NCBI Official Synonym Full Names: CD5 molecule
• NCBI Official Symbol: CD5
• NCBI Official Synonym Symbols: T1; LEU1
• NCBI Protein Information: T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1
• UniProt Protein Name: T-cell surface glycoprotein CD5
• UniProt Gene Name: CD5
• UniProt Synonym Gene Names: LEU1
• UniProt Entry Name: CD5_HUMAN