Mouse anti-Human CD61/Integrin 3/Platelet Glycoprotein IIIa Monoclonal Antibody | anti-ITGB3 antibody

CD61/Integrin 3/Platelet Glycoprotein IIIa (Platelet Marker)

Cat. Num. AAA215043

• Gene Names: ITGB3; GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: CD61/Integrin 3/Platelet Glycoprotein IIIa, Antibody; CD61/Integrin 3/Platelet Glycoprotein IIIa (Platelet Marker); BDPLT2; GP3A; GPIIIa; GT; HPA 1; HPA 4; Integrin beta-3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; PTP; anti-ITGB3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b, kappa
• Clone Number: ITGB3/2145
• Specificity: Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 788

• Applicable Applications for anti-ITGB3 antibody: IHC (Immunohistochemistry)
• Positive Control: U937, KG1a, HEL cells. Spleen.
• Immunogen: Recombinant human ITGB3 protein fragment (aa 385-490) (exact sequence is proprietary)
• Cellular Localization: Cell Surface
• Hu-chromosome Location: 17q21.32
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS_PAGE

(SDS-PAGE Analysis Purified CD61 Mouse Monoclonal Antibody (ITGB3/2145).)

IHC (Immunohistochemisry)

(Formalin-fixed, paraffin-embedded human Kidney stained with CD61 Mouse Monoclonal Antibody (ITGB3/2145).)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Spleen stained with CD61 Mouse Monoclonal Antibody (ITGB3/2145).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Tonsil stained with CD61 Mouse Monoclonal Antibody (ITGB3/2145).)

References

Gatter KC, Cordell JL, Turley H, Heryet A, Kieffer N, Anstee DJ, et al. The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens. Histopathology 1988; 13:257 -67.

NCBI and Uniprot Product Information

• NCBI GI #: 47078292
• NCBI GeneID: 3690
• NCBI Accession #: NP_000203.2
• NCBI GenBank Nucleotide #: NP_000203.2
• UniProt Accession #: P05106
• Molecular Weight: 105kDa & 90kDa
• NCBI Official Full Name: integrin beta-3
• NCBI Official Synonym Full Names: integrin subunit beta 3
• NCBI Official Symbol: ITGB3
• NCBI Official Synonym Symbols: GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
• NCBI Protein Information: integrin beta-3
• UniProt Protein Name: Integrin beta-3
• UniProt Gene Name: ITGB3
• UniProt Synonym Gene Names: GP3A; GPIIIa
• UniProt Entry Name: ITB3_HUMAN