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Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using HNF1A Mouse Monoclonal Antibody (HNF1A/2087). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse anti-Human HNF1A Monoclonal Antibody | anti-HNF1A antibody
HNF1A (Pancreatic Tumor Suppressor)
Gene Names
HNF1A; HNF1; LFB1; TCF1; HNF4A; MODY3; TCF-1; HNF-1A; IDDM20
Reactivity
Human
Applications
Immunohistochemistry, ELISA
Purity
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Synonyms
HNF1A, Antibody; HNF1A (Pancreatic Tumor Suppressor); Albumin proximal factor; Hepatic nuclear factor 1 alpha; Hepatic transcription factor 1 alpha; HNF-1A; Interferon production regulator factor; LFB1; LFB1 hepatic nuclear factor; Liver specific transcription factor LFB1; Maturity onset diabetes of the young 3 (MODY3); TCF1; Transcription factor 1 hepatic; anti-HNF1A antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
HNF1A/2087
Specificity
HNF1A belongs to the homeobox protein family and is an essential transcription factor for many hepatic genes involved in detoxification, homeostasis and metabolisms of glucose, lipid, steroid and amino acid. In addition, HNF1A is an important component of the transcriptional networks governing embryonic pancreas development and differentiation. as well as maintaining the growth and function of islet beta cells in adult. HNF1A (Hepatocyte nuclear factor 1 alpha) is a transcription factor that is known to regulate pancreatic differentiation and maintain homeostasis of endocrine pancreas. Recently, genome-wide association studies have implicated HNF1A as a susceptibility gene for pancreatic cancer.
Purity/Purification
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
572
Applicable Applications for anti-HNF1A antibody
IHC (Immunohistochemistry), ELISA
Immunogen
Recombinant fragment (around aa 214-339) of human HNF1A protein (exact sequence is proprietary)
Positive Control
Jurkat Cells. Small Intestine or Pancreas
Cellular Localization
Nucleus
Research Areas
Autophagy, Cancer, Cardiovascular, Developmental Biology, Nuclear Marker, Pancreatic Cancer
Preparation and Storage
Antibody with azide: store at 2 to 8°C.
Antibody without azide: store at -20 to -80°C.
Antibody is stable for 12 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80°C.
Antibody is stable for 12 months. Non-hazardous. No MSDS required.
Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using HNF1A Mouse Monoclonal Antibody (HNF1A/2087). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using HNF1A Mouse Monoclonal Antibody (HNF1A/2087). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS_PAGE
(SDS-PAGE Analysis Purified HNF1A Mouse Monoclonal Antibody (HNF1A/2087). Confirmation of Integrity and Purity of Antibody.)
SDS_PAGE
(SDS-PAGE Analysis Purified HNF1A Mouse Monoclonal Antibody (HNF1A/2087). Confirmation of Integrity and Purity of Antibody.)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Pancreas stained with HNF1A Mouse Monoclonal Antibody (HNF1A/2087).)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Pancreas stained with HNF1A Mouse Monoclonal Antibody (HNF1A/2087).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Pancreas stained with HNF1A Mouse Monoclonal Antibody (HNF1A/2087).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Pancreas stained with HNF1A Mouse Monoclonal Antibody (HNF1A/2087).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Small Intestine stained with HNF1A Mouse Monoclonal Antibody (HNF1A/2087).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Small Intestine stained with HNF1A Mouse Monoclonal Antibody (HNF1A/2087).)
References
Bach, I., et al. 1993. EMBO J. 12: 4229-4242.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
79kDa
NCBI Official Full Name
hepatocyte nuclear factor 1-alpha isoform 2
NCBI Official Synonym Full Names
HNF1 homeobox A
NCBI Official Symbol
HNF1A
NCBI Official Synonym Symbols
HNF1; LFB1; TCF1; HNF4A; MODY3; TCF-1; HNF-1A; IDDM20
NCBI Protein Information
hepatocyte nuclear factor 1-alpha
UniProt Protein Name
Hepatocyte nuclear factor 1-alpha
UniProt Gene Name
HNF1A
UniProt Synonym Gene Names
TCF1; HNF-1-alpha; HNF-1A; LFB1; TCF-1
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Product Notes
The HNF1A hnf1a (Catalog #AAA214822) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HNF1A (Pancreatic Tumor Suppressor) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HNF1A can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the HNF1A hnf1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HNF1A, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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