IHC (Immunohiostchemistry)
(Pygopus 2 Antibody Immunohistochemistry on an FFPE Lung Neuroendocrine Tumor Tissue)
Mouse Pygopus 2/Pygo 2 Monoclonal Antibody | anti-Pygo2 antibody
Pygopus 2/Pygo 2 (BSB-156)
Reactivity
Human, Mouse, Rat
Synonyms
Pygopus 2/Pygo 2, Antibody; Pygopus 2/Pygo 2 (BSB-156); pygopus 2; pygo2; anti-pygopus 2; pygopus-2; anti-pygo2; anti-pygo 2; pygo 2; anti pygo-2; pygo-2; anti-Pygo2 antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
BSB-156
Form/Format
Paraffin, Frozen
Pygopus 2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Pygopus 2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the internal region of the human
Control
Fallopian Tube, Adrenal Gland, Kidney, Transitional Cell Carcinoma, Lung Adenocarcinoma, Lung Neuroendocrine Cancer, Papillary Thyroid Carcinoma
Localization
Cytoplasmic, Membranous, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
IHC (Immunohiostchemistry)
(Pygopus 2 Antibody Immunohistochemistry on an FFPE Lung Neuroendocrine Tumor Tissue)
IHC (Immunohiostchemistry)
(Pygopus 2 Antibody Immunohistochemistry on an FFPE Lung Neuroendocrine Tumor Tissue)
Dilution Info
Dilution Info
Related Product Information for anti-Pygo2 antibody
Pygopus Family PHD Finger 2 (PYGO2) is a protein-coding gene associated with G-protein coupled receptor (GPCR) and Wnt signaling pathways, chromatin binding and histone acetyltransferase regulator activity. Pygo2 as a Wnt signaling pathway component has been detected in multiple cancer types.
One study found that abnormal Pygopus 2 antibody expression was associated with poor differentiation and a high tumor, node, and metastases stage and poor prognosis in non-small cell lung cancer (NSCLC) patients, therefore abnormal Pygo2 qntibody expression may be a marker for advanced NSCLC. Another study found that 59% of the patient tumor specimens exhibited positive Pygopus 2 antibody immunohistochemistry staining and increased intensity with the grade of malignancy, especially for WHO grade III and IV.
High-level expression has been reported in gliomas compared with normal brain tissues, which suggest an important role of Pygo2 in brain tumor progression. In a Colorectal Cancer study, the expression pattern of Pygo2 was evaluated by immunohistochemistry in tumor tissues and their normal margins, and found the expression of pygopus 2 antibody was detected in all tumor tissues. Furthermore, this expression was significantly higher in Colorectal Cancer samples than in normal tissues, and a significant association was found between Pygo2 protein expression in Colorectal Cancer and tumor cell metastasis to the lymph nodes. Pygo2 is also associated with Oligospermia.
One study found that abnormal Pygopus 2 antibody expression was associated with poor differentiation and a high tumor, node, and metastases stage and poor prognosis in non-small cell lung cancer (NSCLC) patients, therefore abnormal Pygo2 qntibody expression may be a marker for advanced NSCLC. Another study found that 59% of the patient tumor specimens exhibited positive Pygopus 2 antibody immunohistochemistry staining and increased intensity with the grade of malignancy, especially for WHO grade III and IV.
High-level expression has been reported in gliomas compared with normal brain tissues, which suggest an important role of Pygo2 in brain tumor progression. In a Colorectal Cancer study, the expression pattern of Pygo2 was evaluated by immunohistochemistry in tumor tissues and their normal margins, and found the expression of pygopus 2 antibody was detected in all tumor tissues. Furthermore, this expression was significantly higher in Colorectal Cancer samples than in normal tissues, and a significant association was found between Pygo2 protein expression in Colorectal Cancer and tumor cell metastasis to the lymph nodes. Pygo2 is also associated with Oligospermia.
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Product Notes
The Pygo2 (Catalog #AAA59388) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Pygopus 2/Pygo 2 (BSB-156) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Pygopus 2/Pygo 2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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