Mouse anti-Human RCAS1/Estrogen Receptor Binding Site Associated, Antigen 9 Monoclonal Antibody | anti-EBAG9 antibody

RCAS1/Estrogen Receptor Binding Site Associated, Antigen 9

Cat. Num. AAA215279

• Gene Names: EBAG9; EB9; PDAF
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: RCAS1/Estrogen Receptor Binding Site Associated, Antigen 9, Antibody; RCAS1/Estrogen Receptor Binding Site Associated, Antigen 9; BAG9; cancer associated surface antigen; cancer associated surface antigen RCAS1; EB9; estrogen receptor binding fragment associated gene 9; PDAF; receptor binding cancer antigen expressed on SiSo cells; anti-EBAG9 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a, kappa
• Clone Number: CPTC-EBAG9-2
• Specificity: EBAG9, also known as RCAS1, is an estrogen-transcribed protein. Soluble and membranous RCAS1 proteins may play a role in the immune escape of tumor cells by promoting T lymphocyte inhibition of growth and apoptosis. RCAS1 is expressed in a wide variety of cancers, including uterine, ovarian, and lung cancer cells, and acts as a ligand for a putative receptor present on peripheral lymphocytes. RCAS1 is highly expressed not only in cancer cells but also in non-tumor bile duct cells subject to immune attack. RCAS1 inhibits the in vitro growth of receptor-expressing cells and induces apoptosis, contributing to the ability of tumor cells to evade host immune surveillance. High expression of RCAS1 significantly correlates with tumor progression and with poor outcome for many cancer patients.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 213

• Applicable Applications for anti-EBAG9 antibody: IHC (Immunohistochemistry)
• Positive Control: MCF-7, Jurkat; 293 cell lysates; Human skeletal muscle tissue.
• Immunogen: Recombinant full-length human EBAG9 protein
• Cellular Localization: Golgi apparatus.
• Hu-chromosome Location: 8q23.2
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified RCAS1 Mouse Monoclonal Antibody (CPTC-EBAG9-2). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Tonsil stained with RCAS1 Mouse Monoclonal Antibody (CPTC-EBAG9-2).)

References

1. Ruder, C. et al. (2009) J Clin Invest 119, 2184-203. 2. Watanabe, T. et al. (1998) Mol Cell Biol 18, 442-9.

NCBI and Uniprot Product Information

• NCBI GI #: 8928283
• NCBI GeneID: 9166
• UniProt Accession #: O00559
• Molecular Weight: 32kDa
• NCBI Official Full Name: Receptor-binding cancer antigen expressed on SiSo cells
• NCBI Official Synonym Full Names: estrogen receptor binding site associated antigen 9
• NCBI Official Symbol: EBAG9
• NCBI Official Synonym Symbols: EB9; PDAF
• NCBI Protein Information: receptor-binding cancer antigen expressed on SiSo cells
• UniProt Protein Name: Receptor-binding cancer antigen expressed on SiSo cells
• UniProt Gene Name: EBAG9
• UniProt Synonym Gene Names: RCAS1
• UniProt Entry Name: RCAS1_HUMAN