Mouse anti-Human RET Proto-oncogene Monoclonal Antibody | anti-RET antibody

RET Proto-oncogene

Cat. Num. AAA215181

• Gene Names: RET; PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1
• Reactivity: Human
• Applications: ELISA
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: RET Proto-oncogene, Antibody; RET Proto-oncogene; Cadherin family member 12 (CDHF12); Cadherin related family member 16 (CDHR16); ELKS; HSCR1; Hydroxyaryl protein kinase; MEN2A; MEN2B; MTC1; Multiple endocrine neoplasia and medullary thyroid carcinoma 1; Oncogene RET; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor ret; PTC; RET; RET ELE1; RET51; RET9; anti-RET antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b, kappa
• Clone Number: RET/2663
• Specificity: The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system; in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney.Alterations in RETgene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung's disease.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 1072

• Applicable Applications for anti-RET antibody: ELISA
• Positive Control: Breast, Prostate or Colon Carcinoma.
• Immunogen: Recombinant fragment (around aa 702-848) of human RET protein (exact sequence is proprietary)
• Cellular Localization: Cytoplasmic, Cell Surface and Nuclear
• Hu-chromosome Location: 10q11.21
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human prostate carcinoma stained with RET Mouse Monoclonal Antibody (RET/2663).)

IHC (Immunohistochemisry)

(Formalin-fixed, paraffin-embedded human prostate carcinoma stained with RET Mouse Monoclonal Antibody (RET/2663).)

Application Data

(Analysis of Protein Array containing more than 19,000 full-length human proteins using RET Mouse Monoclonal Antibody (RET/2663). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.)

SDS-PAGE

(SDS-PAGE Analysis of Purified RET Mouse Monoclonal Antibody (RET/2663). Confirmation of Purity and Integrity of Antibody.)

References

Airaksinen, M.S. et al. (1999) Mol Cell Neurosci 13, 313-25.

NCBI and Uniprot Product Information

• NCBI GI #: 10862701
• NCBI GeneID: 5979
• NCBI Accession #: NP_065681.1
• NCBI GenBank Nucleotide #: NP_065681.1
• UniProt Accession #: P07949
• Molecular Weight: 150kDa (precursor); 170kDa (Mature)
• NCBI Official Full Name: proto-oncogene tyrosine-protein kinase receptor Ret isoform c
• NCBI Official Synonym Full Names: ret proto-oncogene
• NCBI Official Symbol: RET
• NCBI Official Synonym Symbols: PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1
• NCBI Protein Information: proto-oncogene tyrosine-protein kinase receptor Ret
• UniProt Protein Name: Proto-oncogene tyrosine-protein kinase receptor Ret
• UniProt Gene Name: RET
• UniProt Synonym Gene Names: CDHF12; CDHR16; PTC; RET51
• UniProt Entry Name: RET_HUMAN