WB (Western Blot)
(APH1 antibodyWestern blot analysis of APH1 in RAW264.7 cell lysate with APH1 antibody at (A) 0.5, (B) 1 and (C) 2 ?g/mL)
Rabbit anti-Human, Mouse APH1 Polyclonal Antibody | anti-APH1A antibody
APH1 Antibody
Gene Names
APH1A; APH-1; APH-1A; CGI-78; 6530402N02Rik
Reactivity
Human, Mouse
Applications
Western Blot, ELISA
Purity
APH1 Antibody is affinity chromatography purified via peptide column.
Synonyms
APH1, Antibody; APH1 Antibody; APH1; APH-1; APH-1A; CGI-78; 6530402N02Rik; PSF; UNQ579/PRO1141; Gamma-secretase subunit APH-1A; Aph-1alpha; APH-1a; anterior pharynx defective 1 homolog A (C. elegans); anti-APH1A antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
APH1 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid; APH1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration
1 mg/mL (varies by lot)
Sequence Length
247
Applicable Applications for anti-APH1A antibody
WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
APH1 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human APH1a.
The immunogen is located within amino acids 40 - 90 of APH1.
The immunogen is located within amino acids 40 - 90 of APH1.
Positive Control
- RAW 264.7 Cell Lysate
Preparation and Storage
APH1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
WB (Western Blot)
(APH1 antibodyWestern blot analysis of APH1 in RAW264.7 cell lysate with APH1 antibody at (A) 0.5, (B) 1 and (C) 2 ?g/mL)
WB (Western Blot)
(APH1 antibodyWestern blot analysis of APH1 in RAW264.7 cell lysate with APH1 antibody at (A) 0.5, (B) 1 and (C) 2 ?g/mL)
Related Product Information for anti-APH1A antibody
APH1 Antibody: APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Anterior pharynx defective 1 homolog A (C. elegans)
NCBI Official Synonym Full Names
APH1A gamma secretase subunit
NCBI Official Symbol
APH1A
NCBI Official Synonym Symbols
APH-1; APH-1A; CGI-78; 6530402N02Rik
NCBI Protein Information
gamma-secretase subunit APH-1A; aph-1alpha; presenilin-stabilization factor; anterior pharynx defective 1 homolog A
UniProt Protein Name
Gamma-secretase subunit APH-1A
UniProt Gene Name
APH1A
UniProt Synonym Gene Names
PSF; APH-1a
UniProt Entry Name
APH1A_HUMAN
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Product Notes
The APH1A aph1a (Catalog #AAA39541) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APH1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's APH1 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the APH1A aph1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APH1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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