IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Collagen IV antibody.)
Rabbit anti-Human, Mouse Collagen IV Polyclonal Antibody | anti-COL4A1 antibody
Collagen IV Antibody
Gene Names
COL4A1; BSVD; RATOR
Reactivity
Human, Mouse
Applications
Immunohistochemistry, Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
Collagen IV, Antibody; Collagen IV Antibody; COL4A1 NC1 domain; COLLAGEN OF BASEMENT MEMBRANE; ALPHA-1 CHAIN ARRESTEN; alpha 1 type IV collagen preproprotein; collagen IV alpha-1 polypeptide; anti-COL4A1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total Collagen IV protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
519
Applicable Applications for anti-COL4A1 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from human Collagen IV.
Target Name
Collagen IV
Preparation and Storage
Store at -20 degree C
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Collagen IV antibody.)
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Collagen IV antibody.)
WB (Western Blot)
(Western blot analysis of extracts from HeLa cells, using Collagen IV antibody.)
WB (Western Blot)
(Western blot analysis of extracts from HeLa cells, using Collagen IV antibody.)
Related Product Information for anti-COL4A1 antibody
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.Mary K. Chelberg, Cancer Res., Sep 1989; 49: 4796 - 4802.Patricia L. Graham, J. Cell Biol., Jun 1997; 137: 1171.PJ Lein, J. Cell Biol., Apr 1991; 113: 417.EC Tsilibary, J. Biol. Chem., Dec 1988; 263: 19112 - 19118.
Product Categories/Family for anti-COL4A1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
127,981 Da
NCBI Official Full Name
collagen alpha-1(IV) chain isoform 2
NCBI Official Synonym Full Names
collagen, type IV, alpha 1
NCBI Official Symbol
COL4A1
NCBI Official Synonym Symbols
BSVD; RATOR
NCBI Protein Information
collagen alpha-1(IV) chain
UniProt Protein Name
Collagen alpha-1(IV) chain
UniProt Gene Name
COL4A1
UniProt Entry Name
CO4A1_HUMAN
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Product Notes
The COL4A1 col4a1 (Catalog #AAA304307) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Collagen IV Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Collagen IV can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the COL4A1 col4a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Collagen IV, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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