Rabbit Estrogen receptor Polyclonal Antibody | anti-ESR1 antibody

Anti-Estrogen Receptor Antibody

Cat. Num. AAA46025

• Gene Names: ESR1; ER; ESR; Era; ESRA; ESTRR; NR3A1
• Reactivity: Reactis with: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: Estrogen receptor, Antibody; Anti-Estrogen Receptor Antibody; anti-ESR1 antibody

• Host: Rabbit
• Reactivity: Reactis with: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other species
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Sequence Length: 595

• Applicable Applications for anti-ESR1 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Immunogen: E.coli-derived human Estrogen Receptor recombinant protein (Position: F425-V595). Human Estrogen Receptor shares 89% and 88% amino acid (aa) sequences identity with mouse and rat Estrogen Receptor, respectively.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

IHC (Immunohistochemisry)

(Anti- Estrogen Receptor antibody, AAA46025, IHC(P)IHC(P): Human Mammary Cancer Tissue)

WB (Western Blot)

(Anti- Estrogen Receptor antibody, AAA46025, Western blottingAll lanes: Anti Estrogen Receptor (AAA46025) at 0.5ug/mlWB: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 66KDObserved bind size: 66KD)

WB (Western Blot)

(Anti- Estrogen Receptor antibody, AAA46025, Western blottingAll lanes: Anti Estrogen Receptor (AAA46025) at 0.5ug/mlWB: Recombinant Human ER Protein 0.5ngPredicted bind size: 37KDObserved bind size: 37KD)

Related Product Information for anti-ESR1 antibody

Description: Estrogen receptor alpha (ER-α), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. In humans, ER-α is encoded by the gene ESR1 (Estrogen Receptor 1). It is mapped to 6q25.1. This gene is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, it also play a role in other tissues such as bone.

NCBI and Uniprot Product Information

• NCBI GI #: 62821794
• NCBI GeneID: 2099
• NCBI Accession #: NP_000116.2
• NCBI GenBank Nucleotide #: NM_000125.3
• UniProt Accession #: P03372; Q13511; Q14276; Q5T5H7; Q6MZQ9; Q9NU51; Q9UDZ7; Q9UIS7
• NCBI Official Full Name: estrogen receptor isoform 1
• NCBI Official Synonym Full Names: estrogen receptor 1
• NCBI Official Symbol: ESR1
• NCBI Official Synonym Symbols: ER; ESR; Era; ESRA; ESTRR; NR3A1
• NCBI Protein Information: estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1
• UniProt Protein Name: Estrogen receptor
• UniProt Gene Name: ESR1
• UniProt Synonym Gene Names: ESR; NR3A1; ER
• UniProt Entry Name: ESR1_HUMAN