ICC (Immunocytochemistry)
(Immunocytochemistry of GITRL in THP-1 cells with GITRL antibody at 10 μg/mL.)
Rabbit anti-Human, Mouse GITRL Polyclonal Antibody | anti-TNFSF18 antibody
GITRL Antibody
Gene Names
TNFSF18; TL6; AITRL; GITRL; hGITRL
Reactivity
Human, Mouse
Applications
Immunocytochemistry, Western Blot, ELISA
Purity
GITRL Antibody is Protein A purified.
Synonyms
GITRL, Antibody; GITRL Antibody; GITRL; TL6; AITRL; hGITRL; UNQ149/PRO175; Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; tumor necrosis factor (ligand) superfamily, member 18; anti-TNFSF18 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
GITRL Antibody is Protein A purified.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
177
Applicable Applications for anti-TNFSF18 antibody
ICC (Immunocytochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
GITRL antibody was raised against purified recombinant human GITR ligand.
Buffer
GITRL Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
GITRL antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ICC (Immunocytochemistry)
(Immunocytochemistry of GITRL in THP-1 cells with GITRL antibody at 10 μg/mL.)
ICC (Immunocytochemistry)
(Immunocytochemistry of GITRL in THP-1 cells with GITRL antibody at 10 μg/mL.)
WB (Western Blot)
(Western blot analysis of (A) 5 ng, (B) 25 ng, and (C) 50 ng of purified recombinant GITRL with ITRL antibody at 1 μg/mL.)
WB (Western Blot)
(Western blot analysis of (A) 5 ng, (B) 25 ng, and (C) 50 ng of purified recombinant GITRL with ITRL antibody at 1 μg/mL.)
Related Product Information for anti-TNFSF18 antibody
GITRL Antibody: The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-κB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
22,724 Da
NCBI Official Full Name
Tumor necrosis factor ligand superfamily member 18
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 18
NCBI Official Symbol
TNFSF18
NCBI Official Synonym Symbols
TL6; AITRL; GITRL; hGITRL
NCBI Protein Information
tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 18
UniProt Gene Name
TNFSF18
UniProt Synonym Gene Names
AITRL; GITRL; TL6; AITRL; hGITRL
UniProt Entry Name
TNF18_HUMAN
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Product Notes
The TNFSF18 tnfsf18 (Catalog #AAA39866) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GITRL Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GITRL can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the TNFSF18 tnfsf18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GITRL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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