WB (Western Blot)
(Western blot analysis of extracts from cos-7 cells (Lane 2), using GRK2 (Ab-86) antiobdy. The lane on the left is treated with synthesized peptide.)
Rabbit anti-Human, Mouse GRK2 Polyclonal Antibody | anti-GRK2 antibody
GRK2 (Ab-86) Antibody
Gene Names
ADRBK1; GRK2; BARK1; BETA-ARK1
Reactivity
Human, Mouse
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
GRK2, Antibody; GRK2 (Ab-86) Antibody; ADRBK1; adrenergic; beta; receptor kinase 1; ARBK1; anti-GRK2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total ADRBK1protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
689
Applicable Applications for anti-GRK2 antibody
WB (Western Blot)
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from N-terminal of human ADRBK1.
Target Name
GRK2
Preparation and Storage
Store at -20 degree C
WB (Western Blot)
(Western blot analysis of extracts from cos-7 cells (Lane 2), using GRK2 (Ab-86) antiobdy. The lane on the left is treated with synthesized peptide.)
WB (Western Blot)
(Western blot analysis of extracts from cos-7 cells (Lane 2), using GRK2 (Ab-86) antiobdy. The lane on the left is treated with synthesized peptide.)
WB (Western Blot)
(Western blot analysis of extracts from NIH-3T3 cells, using GRK2 (Ab-86) antibody.)
WB (Western Blot)
(Western blot analysis of extracts from NIH-3T3 cells, using GRK2 (Ab-86) antibody.)
Related Product Information for anti-GRK2 antibody
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.Benovic J.L., FEBS Lett. 283:122-126(1991).Chuang T.T., J. Biol. Chem. 267:6886-6892(1992).Penn R.B., J. Biol. Chem. 269:14924-14930(1994).
Product Categories/Family for anti-GRK2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
79,574 Da
NCBI Official Full Name
beta-adrenergic receptor kinase 1
NCBI Official Synonym Full Names
adrenergic, beta, receptor kinase 1
NCBI Official Symbol
ADRBK1
NCBI Official Synonym Symbols
GRK2; BARK1; BETA-ARK1
NCBI Protein Information
beta-adrenergic receptor kinase 1
UniProt Protein Name
Beta-adrenergic receptor kinase 1
UniProt Gene Name
ADRBK1
UniProt Synonym Gene Names
BARK; BARK1; GRK2; Beta-ARK-1
UniProt Entry Name
ARBK1_HUMAN
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Product Notes
The GRK2 adrbk1 (Catalog #AAA301923) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GRK2 (Ab-86) Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GRK2 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the GRK2 adrbk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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