Application Data
(Image: Western blot analysis. Blot of SHSY-5Y cell lysate (lane 1) 1) and HeLa cell lysate (lane 2) was probed with HSP60 (CH22117) at 1: 20,000. This antibody recognizes cleanly and strongly the Hsp60 protein at 60 kDa)
HSP60 Polyclonal Antibody | anti-HSP60 antibody
Hsp60, polyclonal antibody, chicken
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunofluorescence, Immunocytochemistry
Synonyms
HSP60, Antibody; Hsp60, polyclonal antibody, chicken; anti-HSP60 antibody
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Form/Format
Liquid
Sequence Length
566
Applicable Applications for anti-HSP60 antibody
WB (Western Blot), IHC (Immunohistochemistry), IF (Immunofluorescence), ICC (Immunocytochemistry)
Application Data
(Image: Western blot analysis. Blot of SHSY-5Y cell lysate (lane 1) 1) and HeLa cell lysate (lane 2) was probed with HSP60 (CH22117) at 1: 20,000. This antibody recognizes cleanly and strongly the Hsp60 protein at 60 kDa)
Application Data
(Image: Western blot analysis. Blot of SHSY-5Y cell lysate (lane 1) 1) and HeLa cell lysate (lane 2) was probed with HSP60 (CH22117) at 1: 20,000. This antibody recognizes cleanly and strongly the Hsp60 protein at 60 kDa)
Application Data
(Image: HeLa cells were stained (green). Blue is DAPI staining of DNA. The HSP60 antibody reveals strong staining in mitochondria.)
Application Data
(Image: HeLa cells were stained (green). Blue is DAPI staining of DNA. The HSP60 antibody reveals strong staining in mitochondria.)
Related Product Information for anti-HSP60 antibody
The heat shock proteins were discovered, as the name suggests, since they are heavily upregulated when cells are stressed by temperatures above the normal physiological range. They are expressed in unstressed cells also and have a normal function as chaperones, helping other proteins to fold correctly, and are required in much greater amounts if the cell or tissue is stressed by heat. The increased levels are generated transcriptionally under the influence of a powerful transcription factor, the heat shock factor 1 (HSF1).
The different heat shock proteins were originally named based on their SDS-PAGE mobility, so HSP60 has an apparent molecular weight of 60 kDa. It is an abundant protein in mitochondria and is typically responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. HSP60 aids in the folding and conformation maintenance of approximately 15-30% of all cellular proteins. In addition to its role as a heat shock protein, HSP60 plays an important role in the transport and maintenance of mitochondrial proteins as well as the transmission and replication of mitochondrial DNA. HSP60 has been implicated in the initiation and/or progression of some subtypes of Cardiovascular Disease (CVD), implying its potential as a biomarker with applications for identification, assessing prognosis and response to treatment, as well as for preventing and treating CVD. The HGNC name for this protein is HSBD1.
The different heat shock proteins were originally named based on their SDS-PAGE mobility, so HSP60 has an apparent molecular weight of 60 kDa. It is an abundant protein in mitochondria and is typically responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. HSP60 aids in the folding and conformation maintenance of approximately 15-30% of all cellular proteins. In addition to its role as a heat shock protein, HSP60 plays an important role in the transport and maintenance of mitochondrial proteins as well as the transmission and replication of mitochondrial DNA. HSP60 has been implicated in the initiation and/or progression of some subtypes of Cardiovascular Disease (CVD), implying its potential as a biomarker with applications for identification, assessing prognosis and response to treatment, as well as for preventing and treating CVD. The HGNC name for this protein is HSBD1.
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
60,202 Da
NCBI Official Full Name
HSP60
UniProt Protein Name
HSP60
UniProt Gene Name
hsp60
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Product Notes
The HSP60 hsp60 (Catalog #AAA76566) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Hsp60, polyclonal antibody, chicken reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HSP60 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), IF (Immunofluorescence), ICC (Immunocytochemistry). Researchers should empirically determine the suitability of the HSP60 hsp60 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HSP60, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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