IHC (Immunohiostchemistry)
(Immunochemical staining of human IDO1 in human renal carcinoma with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human IDO Polyclonal Antibody | anti-IDO1 antibody
Anti-IDO Antibody, Rabbit Polyclonal
Gene Names
IDO1; IDO; INDO; IDO-1
Reactivity
Human
Applications
Immunohistochemistry, ELISA
Purity
Protein A & Antigen Affinity
Synonyms
IDO, Antibody; Anti-IDO Antibody, Rabbit Polyclonal; IDO1/Indoleamine 2, 3-dioxygenase Antibody, Rabbit PAb, Antigen Affinity Purified; indoleamine 2, 3-dioxygenase 1; Anti-IDO Antibody; Anti-IDO-1 Antibody; Anti-INDO Antibody; Anti-Indoleamine 2, 3-dioxygenase Antibody; anti-IDO1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human IDO1/Indoleamine 2, 3-dioxygenase
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Concentration
1 mg/ml (varies by lot)
Applicable Applications for anti-IDO1 antibody
IHC (Immunohistochemistry), ELISA
Immunogen
Recombinant Human IDO1/Indoleamine 2, 3-dioxygenase Protein
Preparation
Produced in rabbits immunized with purified, recombinant Human IDO1/Indoleamine 2, 3-dioxygenase (rh IDO1/Indoleamine 2, 3-dioxygenase). IDO1/Indoleamine 2, 3?dioxygenase specific IgG was purified by Human IDO1/Indoleamine 2, 3-dioxygenase affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium Azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid freeze-thaw cycles
IHC (Immunohiostchemistry)
(Immunochemical staining of human IDO1 in human renal carcinoma with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohiostchemistry)
(Immunochemical staining of human IDO1 in human renal carcinoma with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohistochemistry)
(Immunochemical staining of human IDO1 in human lymph node with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohistochemistry)
(Immunochemical staining of human IDO1 in human lymph node with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-IDO1 antibody
Indoleamine 2, 3-dioxygenase-1, also known as Indoleamine-pyrrole 2, 3-dioxygenase, IDO1, and IDO, is a member of the indoleamine 2, 3-dioxygenase family. IDO1/IDO and tryptophan 2, 3-dioxygenase (TDO) are tryptophan-degrading enzymes that catalyze the first step in tryptophan catabolism via the kynurenine pathway. TDO is widely distributed in both eukaryotes and bacteria. In contrast, IDO has been found only in mammals and yeast. In 27, a third enzyme, indoleamine 2, 3-dioxygenase-2 (IDO2), was discovered. IDO2 is found not only in mammals but also in lower vertebrates. IDO1/IDO is an immunosuppressive molecule inducible in various cells. IDO1/IDO catalyzes the cleavage of the pyrrole ring of tryptophan and incorporates both atoms of a molecule of oxygen. It mediates oxidative cleavage of tryptophan, an amino acid essential for cell proliferation and survival. IDO1/IDO inhibition is proposed to have therapeutic potential in immunodeficiency-associated abnormalities, including cancer. The IDO pathway is activated in multiple tumor types. Selective inhibition of IDO1 may represent an attractive cancer therapeutic strategy via up-regulation of cellular immunity. IDO1/IDO is an enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular microenvironment. Inhibition of IDO pathway might enhance the efficacy of immunotherapeutic strategies for cancer.
Product Categories/Family for anti-IDO1 antibody
References
Barnes NA. et al., 2009, J Immunol. 183 (9): 5768-77. Yuasa HJ. et al., 2009, Comp Biochem Physiol B Biochem Mol Biol. 153 (2): 137-44. L b S. et al., 2009, Cancer Immunol Immunother. 58 (1): 153-7. Liu, X. et al., 2010, Blood.115 (17): 3520-30. Sun, T. et al., 2010, Mol Cell Biochem. 342 (1-2): 29-34. Kiank C. et al., 2010, PLoS One. 5 (7): e11825.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
indoleamine 2,3-dioxygenase 1
NCBI Official Synonym Full Names
indoleamine 2,3-dioxygenase 1
NCBI Official Symbol
IDO1
NCBI Official Synonym Symbols
IDO; INDO; IDO-1
NCBI Protein Information
indoleamine 2,3-dioxygenase 1
UniProt Protein Name
Indoleamine 2,3-dioxygenase 1
UniProt Gene Name
IDO1
UniProt Synonym Gene Names
IDO; INDO; IDO-1
UniProt Entry Name
I23O1_HUMAN
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Product Notes
The IDO1 ido1 (Catalog #AAA255448) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-IDO Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IDO can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the IDO1 ido1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IDO, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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