WB (Western Blot)
(ITM2B Antibody (C-term) western blot analysis in mouse cerebellum,lung tissue lysates (35ug/lane).This demonstrates the ITM2B antibody detected the ITM2B protein (arrow).)
Rabbit ITM2B Polyclonal Antibody | anti-ITM2B antibody
ITM2B Antibody (C-term)
Gene Names
ITM2B; BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B
Reactivity
Mouse (Predicted Reactivity: Monkey)
Applications
Western Blot, Immunohistochemistry, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
ITM2B, Antibody; ITM2B Antibody (C-term); Integral membrane protein 2B; Immature BRI2; imBRI2; Protein E25B; Transmembrane protein BRI; Bri; BRI2; membrane form; Mature BRI2; mBRI2; BRI2 intracellular domain; BRI2 ICD; BRI2C; soluble form; Bri23 peptide; Bri2-23; ABri23; C-terminal peptide; P23 peptide; ITM2B; BRI; anti-ITM2B antibody
Host
Rabbit
Reactivity
Mouse (Predicted Reactivity: Monkey)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This ITM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human ITM2B.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
218-247
Sequence Length
160
Applicable Applications for anti-ITM2B antibody
WB (Western Blot), IHC (Immunohistochemistry), ELISA
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(ITM2B Antibody (C-term) western blot analysis in mouse cerebellum,lung tissue lysates (35ug/lane).This demonstrates the ITM2B antibody detected the ITM2B protein (arrow).)
WB (Western Blot)
(ITM2B Antibody (C-term) western blot analysis in mouse cerebellum,lung tissue lysates (35ug/lane).This demonstrates the ITM2B antibody detected the ITM2B protein (arrow).)
IHC (Immunohistochemistry)
(ITM2B Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ITM2B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohistochemistry)
(ITM2B Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ITM2B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Related Product Information for anti-ITM2B antibody
Amyloid precursor proteins are processed by beta-secretase
and gamma-secretase to produce beta-amyloid peptides which form the
characteristic plaques of Alzheimer disease. This gene encodes a
transmembrane protein which is processed at the C-terminus by furin
or furin-like proteases to produce a small secreted peptide which
inhibits the deposition of beta-amyloid. Mutations which result in
extension of the C-terminal end of the encoded protein, thereby
increasing the size of the secreted peptide, are associated with
two neurogenerative diseases, familial British dementia and
familial Danish dementia.
and gamma-secretase to produce beta-amyloid peptides which form the
characteristic plaques of Alzheimer disease. This gene encodes a
transmembrane protein which is processed at the C-terminus by furin
or furin-like proteases to produce a small secreted peptide which
inhibits the deposition of beta-amyloid. Mutations which result in
extension of the C-terminal end of the encoded protein, thereby
increasing the size of the secreted peptide, are associated with
two neurogenerative diseases, familial British dementia and
familial Danish dementia.
Product Categories/Family for anti-ITM2B antibody
References
Peng, S., et al. Biochem. Biophys. Res. Commun. 393(3):356-361(2010)
Matsuda, S., et al. J. Biol. Chem. 284(23):15815-15825(2009)
Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :
Tsachaki, M., et al. Biotechnol J 3(12):1548-1554(2008)
Kim, J., et al. J. Neurosci. 28(23):6030-6036(2008)
Matsuda, S., et al. J. Biol. Chem. 284(23):15815-15825(2009)
Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :
Tsachaki, M., et al. Biotechnol J 3(12):1548-1554(2008)
Kim, J., et al. J. Neurosci. 28(23):6030-6036(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
30338
NCBI Official Full Name
integral membrane protein 2B
NCBI Official Synonym Full Names
integral membrane protein 2B
NCBI Official Symbol
ITM2B
NCBI Official Synonym Symbols
BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B
NCBI Protein Information
integral membrane protein 2B
UniProt Protein Name
Integral membrane protein 2B
UniProt Gene Name
ITM2B
UniProt Synonym Gene Names
BRI; BRI2; imBRI2; Bri; mBRI2; BRI2 ICD; Bri2-23
UniProt Entry Name
ITM2B_HUMAN
Similar Products
Product Notes
The ITM2B itm2b (Catalog #AAA284727) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 218-247. The ITM2B Antibody (C-term) reacts with Mouse (Predicted Reactivity: Monkey) and may cross-react with other species as described in the data sheet. AAA Biotech's ITM2B can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the ITM2B itm2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ITM2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.