IHC (Immunohiostchemistry)
(Immunohistochemical analysis of ITM2B protein in paraffin embedded Human Kidney tissue using ITM2B antibody)
Mouse ITM2B Monoclonal Antibody | anti-ITM2B antibody
ITM2B antibody
Gene Names
ITM2B; BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B
Applications
Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
ITM2B antibody was purified by affinity chromatography.
Synonyms
ITM2B, Antibody; ITM2B antibody; Monoclonal ITM2B; Anti-ITM2B; Integral membrane protein 2B; BRI; E25B; Transmembrane protein BRI; ITM2B; ITMB 2; ITMB-2; anti-ITM2B antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
1C11
Purity/Purification
ITM2B antibody was purified by affinity chromatography.
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration
500 ug-1 mg/ml (varies by lot)
Sequence Length
266
Applicable Applications for anti-ITM2B antibody
WB (Western Blot), IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry)
Biological Significance
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides whichform the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition ofbeta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
Cross-Reactivity
Human
Immunogen
ITM2B antibody was raised in mouse using a full length recombinant protein of human ITM2B (NP_068839) produced in HEK293T cells, as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of ITM2B protein in paraffin embedded Human Kidney tissue using ITM2B antibody)
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of ITM2B protein in paraffin embedded Human Kidney tissue using ITM2B antibody)
WB (Western Blot)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ITM2B protein (Right) or empty vector (Left) detected with ITM2B antibody)
WB (Western Blot)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ITM2B protein (Right) or empty vector (Left) detected with ITM2B antibody)
Related Product Information for anti-ITM2B antibody
Mouse monoclonal ITM2B antibody
Product Categories/Family for anti-ITM2B antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,283 Da
NCBI Official Full Name
integral membrane protein 2B
NCBI Official Synonym Full Names
integral membrane protein 2B
NCBI Official Symbol
ITM2B
NCBI Official Synonym Symbols
BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B
NCBI Protein Information
integral membrane protein 2B
UniProt Protein Name
Integral membrane protein 2B
UniProt Gene Name
ITM2B
UniProt Synonym Gene Names
BRI; BRI2; imBRI2; Bri; mBRI2; BRI2 ICD; Bri2-23
UniProt Entry Name
ITM2B_HUMAN
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Product Notes
The ITM2B itm2b (Catalog #AAA106915) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's ITM2B can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the ITM2B itm2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ITM2B, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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