IHC (Immunohistochemisry)
(Fig: 3 Immunohistochemical analysis of Livin in formalin-fixed, paraffin embedded human tonsil (secondary nodule) using at 1: 2000. Hematoxylin-eosin counterstain.)
Rabbit Livin Polyclonal Antibody | anti-BIRC7 antibody
Polyclonal Antibody to Livin (KIAP)
Gene Names
BIRC7; KIAP; LIVIN; MLIAP; RNF50; ML-IAP
Reactivity
Rat, Mouse, Human
Applications
Western Blot, Immunohistochemistry, Immunoprecipitation
Purity
Serum
Synonyms
Livin, Antibody; Polyclonal Antibody to Livin (KIAP); BIRC7; KIAP; LIVIN; MLIAP; RNF50; UNQ5800/PRO19607/PRO21344; Kidney inhibitor of apoptosis protein; Livin; ML-IAP; Melanoma inhibitor of apoptosis protein; RING finger protein 50; Antibody to Livin (KIAP); Anti-Livin (KIAP) Antibody; Livin (KIAP) Antibody; anti-BIRC7 antibody
Host
Rabbit
Reactivity
Rat, Mouse, Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Serum
Form/Format
50 ul sera
Sequence Length
298
Applicable Applications for anti-BIRC7 antibody
WB (Western Blot), IHC (Immunohistochemistry), IP (Immunoprecipitation)
Immunogen Information
A synthetic peptide of human Livin, isoform alpha and isoform beta (amino acids 199-217 PELPTPRREVQSESAQEPG) was used as immunogen for this antibody
Antigen
Livin (KIAP)
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
IHC (Immunohistochemisry)
(Fig: 3 Immunohistochemical analysis of Livin in formalin-fixed, paraffin embedded human tonsil (secondary nodule) using at 1: 2000. Hematoxylin-eosin counterstain.)
IHC (Immunohistochemisry)
(Fig: 3 Immunohistochemical analysis of Livin in formalin-fixed, paraffin embedded human tonsil (secondary nodule) using at 1: 2000. Hematoxylin-eosin counterstain.)
IHC (Immunohiostchemistry)
(Fig: 2 Immunohistochemical analysis of Livin in Bouin's-fixed, paraffin-embedded E13.5 mouse embryo (13.5 days post coitum) Bouin's using at 1: 2000. The mother was perfused prior to embryo harvesting. A, brain overview. B, brain. C, spinal cord. D, liver and abdominal wall. Hematoxylin-eosin counterstain.)
IHC (Immunohiostchemistry)
(Fig: 2 Immunohistochemical analysis of Livin in Bouin's-fixed, paraffin-embedded E13.5 mouse embryo (13.5 days post coitum) Bouin's using at 1: 2000. The mother was perfused prior to embryo harvesting. A, brain overview. B, brain. C, spinal cord. D, liver and abdominal wall. Hematoxylin-eosin counterstain.)
WB (Western Blot)
(Fig: 1 Western blot analysis of full-length, recombinant human Livin using at 1: 2000.)
WB (Western Blot)
(Fig: 1 Western blot analysis of full-length, recombinant human Livin using at 1: 2000.)
Related Product Information for anti-BIRC7 antibody
This antibody recognizes Livin, both isoform alpha and isoform beta. Human Livin isoform alpha is a 298 amino acid protein. Livin (BIRC7/KIAP) is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. Some IAP members, like Liven, also have a RING-type finger motif at their carboxyl-terminal which may enhance anti-apoptotic activity. Many RING finger-containing IAPs possess E3 ubiquitin ligase activity, and it has been shown that Liven acts an E3 ubiquitin ligase for targeting the degradation of Smac/DIABLO. Thus degradation of Smac/DIABLO is thought to be a mechanism to enhance Livin anti-apoptotic activity, thereby promoting cell survival. Two splicing variants of Livin, alpha and beta, have been identified. The two isoforms are thought to have different anti-apoptotic properties; however, there are conflicting reports are to whether they actually differ in their biological activities. Liven is expressed at low levels in adult tissues, and relatively higher levels in developmental tissues and in many cancer cells. Certain cancers patients develop autoantibodies against liven and in a number of cancers, Liven is detected only in the tumors but not, or to substantially lower levels, in the corresponding normal adjacent tissue.
Product Categories/Family for anti-BIRC7 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
30,866 Da
NCBI Official Full Name
Baculoviral IAP repeat-containing protein 7
NCBI Official Synonym Full Names
baculoviral IAP repeat containing 7
NCBI Official Symbol
BIRC7
NCBI Official Synonym Symbols
KIAP; LIVIN; MLIAP; RNF50; ML-IAP
NCBI Protein Information
baculoviral IAP repeat-containing protein 7
UniProt Protein Name
Baculoviral IAP repeat-containing protein 7
UniProt Gene Name
BIRC7
UniProt Synonym Gene Names
KIAP; LIVIN; MLIAP; RNF50; KIAP; ML-IAP; Truncated livin; p30-Livin; tLivin
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Product Notes
The BIRC7 birc7 (Catalog #AAA78343) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Livin (KIAP) reacts with Rat, Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's Livin can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), IP (Immunoprecipitation). Researchers should empirically determine the suitability of the BIRC7 birc7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Livin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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