Rabbit MRE11 Polyclonal Antibody | anti-MRE11A antibody

MRE11 Antibody

Cat. Num. AAA39353

• Gene Names: MRE11A; ATLD; HNGS1; MRE11; MRE11B
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: MRE11 Antibody is affinity chromatography purified via peptide column.
• Synonyms: MRE11, Antibody; MRE11 Antibody; MRE11; ATLD; HNGS1; MRE11B; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); anti-MRE11A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: MRE11 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 708

• Applicable Applications for anti-MRE11A antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: MRE11 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus human MRE11.
• Buffer: MRE11 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: MRE11 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of MRE11 in rat lung tissue with MRE11 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of MRE11 in rat lung tissue with MRE11 antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of MRE11 in A549 cell lysate with MRE11 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-MRE11A antibody

MRE11 Antibody: MRE11 is involved in the repair of DNA double strand breaks as part of a complex that includes the Rad50 and NBS1 protein and is thought to act in the same pathway as the A-T mutated (ATM) protein. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for non-homologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Mutations in this protein result in a novel ataxia telangiectasia-like disorder (ATLD). Unlike the ATM protein, MRE11 is necessary proper mammalian development.

NCBI and Uniprot Product Information

• NCBI GI #: 119587336
• NCBI GeneID: 4361
• UniProt Accession #: P49959; O43475; B3KTC7
• Molecular Weight: 81,070 Da
• NCBI Official Full Name: MRE11 meiotic recombination 11 homolog A (S. cerevisiae), isoform CRA_a
• NCBI Official Synonym Full Names: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
• NCBI Official Symbol: MRE11A
• NCBI Official Synonym Symbols: ATLD; HNGS1; MRE11; MRE11B
• NCBI Protein Information: double-strand break repair protein MRE11A; AT-like disease; MRE11 homolog 1; MRE11 homolog A; endo/exonuclease Mre11; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; DNA recombination and repair protein
• UniProt Protein Name: Double-strand break repair protein MRE11A
• UniProt Gene Name: MRE11A
• UniProt Synonym Gene Names: HNGS1; MRE11; MRE11 homolog 1; MRE11 homolog A
• UniProt Entry Name: MRE11_HUMAN