Rabbit Testicular Receptor 2 (TR2) Polyclonal Antibody | anti-NR2C1 antibody

Anti-Testicular Receptor 2 (TR2)

Cat. Num. AAA72810

• Gene Names: Nr2c1; TR2; 80.3; Eenr; Tr2-11; 4831444H07Rik
• Reactivity: Human, mouse, rat
• Applications: Western Blot
• Purity: Neat Serum
• Synonyms: Testicular Receptor 2 (TR2), Antibody; Anti-Testicular Receptor 2 (TR2); anti-NR2C1 antibody

• Host: Rabbit
• Reactivity: Human, mouse, rat
• Clonality: Polyclonal
• Specificity: Specific for the ~64 kDa TR2 protein in Western blots of testes and nuclear extracts from MEL cell lines.
• Purity/Purification: Neat Serum
• Form/Format: neat serum
• Sequence Length: 590

• Applicable Applications for anti-NR2C1 antibody: WB (Western Blot)
• Antigen: Fusion protein from N-terminal peptide of mouse TR2.
• Immunogen Information: Fusion protein from the N-terminal region of mouse TR2
• Immunogen Species: Mouse
• Species Reactivity Note: The antibody has been directly tested for reactivity in mouse, human and rat.
• Biological Significance: Testicular receptor 2 (TR2) is a member of the orphan nuclear receptor family. It is widely expressed at a low level throughout the adult testis. TR2 represses transcription and binds DNA directly interacting with HDAC3 and HDAC4 via DNA-binding domains (Franco et al., 2003). TR2 has also been implicated in regulation of estrogen receptor activity in mammary glands (Hun et al., 2002). In addition, TR2 has recently been shown to form a heterodimer with TR4 that can bind to the direct repeat 6 element of the hepatitis B virus (HBV) enhancer II region thus suppressing HBV gene expression (Lin et al., 2008).
• Preparation and Storage: Store at -20 degree C in undiluted aliquots; stable for at least one year after date of receipt. Avoid freeze/thaw cycles.

Application Data

Related Product Information for anti-NR2C1 antibody

Rabbit polyclonal antibody

References

• Franco PJ, Li G, Wei LN (2003) Interaction of nuclear receptor zinc finger DNA binding domains ith histone deacetylase. Mol Cell Endocrinol. 206(1-2):1-12.
• Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C. (2002) Suppression of estrogen receptor- mediated transcription and cell growth by interaction with TR2 orphan receptor. J Biol Chem. 002 277(37):33571-9.
• Lin TJ, Yang RY, Lee HJ. (2008) Collective repression of the hepatitis B virus enhancer II by human TR4 and TR2 orphan receptors. Hepatol Res. 38(1):79-84.
• Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, Chen YT, Chang C, Yamamoto M, Tanimoto K, Engel JD. "Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4." EMBO J. 2007, 26:2295-306.

NCBI and Uniprot Product Information

• NCBI GI #: 171846245
• NCBI GeneID: 22025
• NCBI Accession #: NP_035759.3
• NCBI GenBank Nucleotide #: NM_011629.3
• UniProt Accession #: Q505F1; P97763; Q0VGP8; Q3UIJ7; Q4U1Z4; Q60927; Q62152; Q8VIJ3
• Molecular Weight: 64
• NCBI Official Full Name: nuclear receptor subfamily 2 group C member 1
• NCBI Official Synonym Full Names: nuclear receptor subfamily 2, group C, member 1
• NCBI Official Symbol: Nr2c1
• NCBI Official Synonym Symbols: TR2; 80.3; Eenr; Tr2-11; 4831444H07Rik
• NCBI Protein Information: nuclear receptor subfamily 2 group C member 1; mTR2; 80-3 cNDA; testicular receptor 2; orphan receptor, TR2-11; orphan nuclear receptor TR2; early embryonic nuclear receptor; nuclear receptor subfamily 2, group H, member 1
• UniProt Protein Name: Nuclear receptor subfamily 2 group C member 1
• UniProt Gene Name: Nr2c1
• UniProt Synonym Gene Names: Tr2; Tr2-11; mTR2
• UniProt Entry Name: NR2C1_MOUSE