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IF (Immunofluorescence)
(Confocal immunofluorescent analysis of TGFBR2 Antibody (N-term) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Rabbit anti-Human, mouse TGFBR2 Polyclonal Antibody | anti-TGFBR2 antibody
TGFBR2 Antibody (N-term)
Gene Names
TGFBR2; AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII
Reactivity
Human, mouse
Applications
Immunofluorescence, Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
TGFBR2, Antibody; TGFBR2 Antibody (N-term); TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II; TGFBR2; anti-TGFBR2 antibody
Host
Rabbit
Reactivity
Human, mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This TGFBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human TGFBR2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.4 (varies by lot)
Sequence Positions
13-40
Sequence Length
592
Applicable Applications for anti-TGFBR2 antibody
IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of TGFBR2 Antibody (N-term) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of TGFBR2 Antibody (N-term) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IHC (Immunohistochemisry)
(TGFBR2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFBR2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohistochemisry)
(TGFBR2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFBR2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(TGFBR2 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the TGFBR2 antibody detected the TGFBR2 protein (arrow).)
WB (Western Blot)
(TGFBR2 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the TGFBR2 antibody detected the TGFBR2 protein (arrow).)
WB (Western Blot)
(Anti-TGFBR2 Antibody (N-term)at 1:2000 dilution + mouse lung lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 65 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
WB (Western Blot)
(Anti-TGFBR2 Antibody (N-term)at 1:2000 dilution + mouse lung lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 65 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Related Product Information for anti-TGFBR2 antibody
This gene encodes a member of the Ser/Thr protein kinase
family and the TGFB receptor subfamily. The encoded protein is a
transmembrane protein that has a protein kinase domain, forms a
heterodimeric complex with another receptor protein, and binds
TGF-beta. This receptor/ligand complex phosphorylates proteins,
which then enter the nucleus and regulate the transcription of a
subset of genes related to cell proliferation. Mutations in this
gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic
Aneurysm Syndrome, and the development of various types of tumors.
Alternatively spliced transcript variants encoding different
isoforms have been characterized.
family and the TGFB receptor subfamily. The encoded protein is a
transmembrane protein that has a protein kinase domain, forms a
heterodimeric complex with another receptor protein, and binds
TGF-beta. This receptor/ligand complex phosphorylates proteins,
which then enter the nucleus and regulate the transcription of a
subset of genes related to cell proliferation. Mutations in this
gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic
Aneurysm Syndrome, and the development of various types of tumors.
Alternatively spliced transcript variants encoding different
isoforms have been characterized.
Product Categories/Family for anti-TGFBR2 antibody
References
Inamoto, S., et al. Cardiovasc. Res. 88(3):520-529(2010)
Bianchini, G., et al. J. Clin. Oncol. 28(28):4316-4323(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, J.N., et al. Toxicology 275 (1-3), 29-35 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Bianchini, G., et al. J. Clin. Oncol. 28(28):4316-4323(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, J.N., et al. Toxicology 275 (1-3), 29-35 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
64568
NCBI Official Full Name
TGF-beta receptor type-2 isoform A
NCBI Official Synonym Full Names
transforming growth factor, beta receptor II (70/80kDa)
NCBI Official Symbol
TGFBR2
NCBI Official Synonym Symbols
AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII
NCBI Protein Information
TGF-beta receptor type-2
UniProt Protein Name
TGF-beta receptor type-2
UniProt Gene Name
TGFBR2
UniProt Synonym Gene Names
TGFR-2; TGF-beta receptor type II; TbetaR-II
UniProt Entry Name
TGFR2_HUMAN
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Product Notes
The TGFBR2 tgfbr2 (Catalog #AAA288196) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 13-40. The TGFBR2 Antibody (N-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TGFBR2 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the TGFBR2 tgfbr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TGFBR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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