Rabbit anti-Human TRIM5 alpha Polyclonal Antibody | anti-TRIM5 antibody

TRIM5 alpha Antibody

Cat. Num. AAA39251

• Gene Names: TRIM5; RNF88; TRIM5alpha
• Reactivity: Human
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: TRIM5 alpha Antibody is affinity chromatography purified via peptide column.
• Synonyms: TRIM5 alpha, Antibody; TRIM5 alpha Antibody; TRIM5 alpha; RNF88; TRIM5alpha; Tripartite motif-containing protein 5; RING finger protein 88; tripartite motif-containing 5; anti-TRIM5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: TRIM5 alpha Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 493

• Applicable Applications for anti-TRIM5 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: TRIM5 alpha antibody was raised against a synthetic peptide corresponding to amino acids near the mid-region of human TRIM5 alpha.
• Buffer: TRIM5 alpha Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TRIM5 alpha antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of TRIM5 alpha in Human Stomach cells with TRIM5 alpha antibody at 10 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemical staining of human stomach using TRIM5 alpha antibody at 2 μg/mL.)

WB (Western Blot)

(Western blot analysis of TRIM5 alpha expression in human stomach (A), thymus (B), and uterus (C) cell lysate with TRIM5 alpha antibody at 2 μg /ml.)

Related Product Information for anti-TRIM5 antibody

TRIM5 alpha Antibody: TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5α variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5α variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5α acts as a natural barrier to cross-species retrovirus transmission.

NCBI and Uniprot Product Information

• NCBI GI #: 14719418
• NCBI GeneID: 85363
• NCBI Accession #: NP_149023
• NCBI GenBank Nucleotide #: NM_033034.1
• UniProt Accession #: Q9C035; Q2MLV4; Q2MLV8; Q2MLV9; Q2MLW1; Q2MLW3; Q2MLW4; A6NGQ1; A8WFA8; D3DQS8; D3DQS9; G3GJY1
• Molecular Weight: 29,677 Da
• NCBI Official Full Name: tripartite motif protein TRIM5 isoform alpha
• NCBI Official Synonym Full Names: tripartite motif containing 5
• NCBI Official Symbol: TRIM5
• NCBI Official Synonym Symbols: RNF88; TRIM5alpha
• NCBI Protein Information: tripartite motif-containing protein 5; ring finger protein 88; tripartite motif protein TRIM5; tripartite motif containing 5 transcript variant iota; tripartite motif containing 5 transcript variant kappa
• UniProt Protein Name: Tripartite motif-containing protein 5
• UniProt Gene Name: TRIM5
• UniProt Synonym Gene Names: RNF88
• UniProt Entry Name: TRIM5_HUMAN