Rabbit anti-Human, Mouse TRIM5 Polyclonal Antibody | anti-TRIM5 antibody

TRIM5 Antibody

Cat. Num. AAA233443

• Gene Names: TRIM5; RNF88; TRIM5alpha
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: >95%, Protein G purified
• Synonyms: TRIM5, Antibody; TRIM5 Antibody; Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5), TRIM5, RNF88; anti-TRIM5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 493

• Applicable Applications for anti-TRIM5 antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Immunogen: Recombinant Human Tripartite motif-containing protein 5 protein (1-493AA)
• Immunogen Species: Homo sapiens (Human)
• Research Area: Epigenetics and Nuclear Signaling
• Target Names: TRIM5
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Upon receipt store at -20°C or -80°C. Avoid repeated freeze.

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded human pancreatic tissue using AAA233443 at dilution of 1:100)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded human tonsil tissue using AAA233443 at dilution of 1:100)

Related Product Information for anti-TRIM5 antibody

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).

NCBI and Uniprot Product Information

• NCBI GI #: 283046694
• NCBI GeneID: 85363
• NCBI Accession #: NP_149023.2
• NCBI GenBank Nucleotide #: NM_033034.2
• UniProt Accession #: Q9C035; Q2MLV4; Q2MLV8; Q2MLV9; Q2MLW1; Q2MLW3; Q2MLW4; A6NGQ1; A8WFA8; D3DQS8; D3DQS9; G3GJY1
• NCBI Official Full Name: tripartite motif-containing protein 5 isoform alpha
• NCBI Official Synonym Full Names: tripartite motif containing 5
• NCBI Official Symbol: TRIM5
• NCBI Official Synonym Symbols: RNF88; TRIM5alpha
• NCBI Protein Information: tripartite motif-containing protein 5
• UniProt Protein Name: Tripartite motif-containing protein 5
• UniProt Gene Name: TRIM5
• UniProt Synonym Gene Names: RNF88