Reactivity
Rat
Specificity
Natural and recombinant Rat IL-2 Ligand
Assay Type
Solid Phase Sandwich ELISA
Samples
Cell culture supernatant, serum, plasma (EDTA, citrate, heparin)
Detection Range
0.03-2.0 ng/mL
Sensitivity
7pg/mL
Assay Time
3 hour
Sample Volume
20 uL
Detection Method
Colorimetric
Preparation and Storage
Store at 4 degree C
Related Product Information for IL-2 elisa kit
Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or antigen-activated T lymphocytes (1, 2). It plays a key role in promoting the clonal expansion of antigen-specific T cells. In addition, IL-2 has been shown to mediate multiple immune responses on a variety of cell types.IL-2 has been found to stimulate growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendocytes. IL-2 is involved in treatment of cancers such as melanoma and renal cell cancer. It plays a key role in promoting the clonal expansion of antigen-specific T cells. In addition, IL-2 has also been shown to mediate multiple immune responses on a variety of cell types.The sequence of rat IL-2 cDNA predicts a 155 amino acid (aa) residue precursor glycoprotein containing a 20 aa residue signal peptide that is cleaved to form the mature protein (3). At the amino acid sequence level, mature rat IL-2 is approximately 80% identical to mouse IL-2 (1-4).The biological effects of IL-2 are mediated by specific cell surface receptor complexes. The functional high-affinity receptor for IL-2 is composed of three distinct polypeptide chains (5, 6).IL-2 stimulates the proliferation of thymocytes; stimulates the proliferation and differentiation of activated B cells; promotes the growth, differentiation and cytocidal activity of monocytes; induces the growth of and cytokine production and cytolytic activity by natural killer cells; enhances the production of lymphocyte-activated killer (LAK) cells; and induces the proliferation and differentiation of oligodendrocytes (1, 2).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
4,762 Da
NCBI Official Full Name
IL-2, partial
NCBI Official Synonym Full Names
interleukin 2
NCBI Official Symbol
IL2
NCBI Official Synonym Symbols
IL-2; TCGF; lymphokine
NCBI Protein Information
interleukin-2
UniProt Protein Name
IL-2 protein
UniProt Gene Name
IL-2
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Product Notes
The Rat IL-2 il-2 (Catalog #AAA309912) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA309912 ELISA Kit recognizes Rat IL-2. It is sometimes possible for the material contained within the vial of "IL-2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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