PROTAC PD-1/PD-L1 degrader-1 Biochemical

PROTAC PD-1/PD-L1 degrader-1

Cat. Num. AAA228449

• Purity: 98%
• Synonyms: PROTAC PD-1/PD-L1 degrader-1; N/A; Adenosine5'-triphosphatedipotassium; PROTAC PD-1/PD-L1 degrader-1 biochemical

• Purity/Purification: 98%

• CAS: 2447066-37-5
• Solubility: <1mg/ml refers to the product slightly soluble or insoluble
• In vitro: PROTAC PD-1/PD-L1 degrader-1 (compound p22) reduces cell surface PD-L1 expression for more than 14%[1]. PROTAC PD-1/PD-L1 degrader-1 (1-10 uM; 24 hours) reduces PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 uM and 10 uM, respectively[1]. Western Blot Analysis[1]Cell Line: MDA-MB-231 cells Concentration: 1-10 uM Incubation Time: 24 hours. Result: Reduced PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 uM and 10 uM, respectively.
• Preparation and Storage: Powder: -20 degree C for 3 years; In solvent: -80 degree C for 2 years

Structure

(ATP dipotassium, CAS 42373-41-1)

Structure

(ATP dipotassium, CAS 42373-41-1)

Related Product Information for PROTAC PD-1/PD-L1 degrader-1 biochemical

PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC 50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner.

References

1. Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57.
2. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.
3. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1beta production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.
4. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.