SDS-PAGE
(The purity of unactive MEK1 was determined to be >90% by densitometry, approx MW 47kDa.)
MEK1 recombinant protein
MEK1, Unactive recombinant protein
Gene Names
MAP2K1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1
Applications
Western Blot
Purity
>90%
Synonyms
MEK1; N/A; MEK1, Unactive recombinant protein; MAP2K1; MKK1; MAPKK1; PRKMK1; MEK1 recombinant protein
Purity/Purification
>90%
Form/Format
Recombinant protein stored in 50mM sodium phosphate , ph 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 2mM DTT, 25%glycerol
Concentration
0.2 ug/ul (varies by lot)
Sequence Length
2603
Applicable Applications for MEK1 recombinant protein
WB (Western Blot), Kinase Assay
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped on dry ice.
SDS-PAGE
(The purity of unactive MEK1 was determined to be >90% by densitometry, approx MW 47kDa.)
SDS-PAGE
(The purity of unactive MEK1 was determined to be >90% by densitometry, approx MW 47kDa.)
Related Product Information for MEK1 recombinant protein
MEK1 is a member of the dual specificity protein kinase family that acts as a mitogen-activated protein kinase (MAPK) kinase. MEK1 lies upstream of MAPK/ERK and stimulates the enzymatic activity of MAPK/ERK upon a wide variety of extra- and intracellular signals. As an essential component of MAPK/ERK signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. Constitutive activation of MEK1 results in cellular transformation. Thus, MEK1 represents a likely target for pharmacologic intervention in proliferative disease such a cancer.
Product Categories/Family for MEK1 recombinant protein
References
1. Sugden, P H. et al: Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors. Cell Signal. 1997 Aug;9(5):337-51.
2. Huynh, H. et al: Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis.
BMC Gastroenterol. 2003 Aug 8;3:19.
2. Huynh, H. et al: Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis.
BMC Gastroenterol. 2003 Aug 8;3:19.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~47 kDa
NCBI Official Full Name
Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase 1
NCBI Official Symbol
MAP2K1
NCBI Official Synonym Symbols
CFC3; MEK1; MKK1; MAPKK1; PRKMK1
NCBI Protein Information
dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
UniProt Protein Name
Dual specificity mitogen-activated protein kinase kinase 1
UniProt Gene Name
MAP2K1
UniProt Synonym Gene Names
MEK1; PRKMK1; MAP kinase kinase 1; MAPKK 1; MKK1; MEK 1
UniProt Entry Name
MP2K1_HUMAN
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Product Notes
The MEK1 map2k1 (Catalog #AAA72938) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's MEK1 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), Kinase Assay. Researchers should empirically determine the suitability of the MEK1 map2k1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MEK1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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