Mouse Adipophilin/Perilipin-2 Monoclonal Antibody | anti-PLIN2 antibody

Adipophilin/Perilipin-2 (Marker of Obesity)

Cat. Num. AAA62937

• Gene Names: PLIN2; ADFP; ADRP
• Reactivity: Human. Others not known.
• Applications: Immunohistochemistry, Immunofluorescence, ELISA
• Synonyms: Adipophilin/Perilipin-2, Antibody; Adipophilin/Perilipin-2 (Marker of Obesity); Adipophilin; ADFP; Adipose differentiation-related protein (ADRP); Perilipin-2 (PLIN2); anti-PLIN2 antibody

• Host: Mouse
• Reactivity: Human. Others not known.
• Clonality: Monoclonal
• Isotype: IgG2b, kappa
• Clone Number: ADFP/1366
• Specificity: Recognizes a protein of 48kDa, which is identified as Adipophilin. It belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases.
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 437

• Applicable Applications for anti-PLIN2 antibody: IHC (Immunohistochemistry), IF (Immunofluorescence), ELISA
• Immunogen: Recombinant human Adipophilin protein fragment (aa249-376)
• Cellular Localization: Cytoplasmic
• Hu-chromosome Location: 9p22.1
• Positive Control: HepG2 or JAR cells. Liver, Adrenal gland or Cerebellum.
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C.; Antibody without azide - store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with p27 Monoclonal Antibody (DCS-72.F6))

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Adrenal stained with Adipophilin Monoclonal Antibody (ADFP/1366).)

References

Kern, P.A., et al. 2004. Perilipin expression in human adipose tissue is elevated with obesity. J. Clin. Endocrinol. Metab. 89: 1352-1358.

NCBI and Uniprot Product Information

• NCBI GI #: 34577059
• NCBI GeneID: 123
• NCBI Accession #: NP_001113.2
• NCBI GenBank Nucleotide #: NM_001122.3
• UniProt Accession #: Q99541; Q9BSC3
• Molecular Weight: 48kDa
• NCBI Official Full Name: perilipin-2
• NCBI Official Synonym Full Names: perilipin 2
• NCBI Official Symbol: PLIN2
• NCBI Official Synonym Symbols: ADFP; ADRP
• NCBI Protein Information: perilipin-2
• UniProt Protein Name: Perilipin-2
• UniProt Gene Name: PLIN2
• UniProt Synonym Gene Names: ADFP; ADRP