Application Data
(Formalin-fixed, paraffin-embedded human Pancreas stained with Alpha-1- Antichymotrypsin Mouse Monoclonal Antibody (AACT/1452))
Mouse anti-Human Alpha-1-Antichymotrypsin (SERPINA3) Monoclonal Antibody | anti-SERPINA3 antibody
Alpha-1-Antichymotrypsin (SERPINA3) (Histiocytoma Marker)
Gene Names
SERPINA3; ACT; AACT; GIG24; GIG25
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
Alpha-1-Antichymotrypsin (SERPINA3), Antibody; Alpha-1-Antichymotrypsin (SERPINA3) (Histiocytoma Marker); SERPINA3; AACT; ACT; Alpha-1-antichymotrypsin; Antichymotrypsin; Cell growth-inhibiting gene 24/25 protein; GIG24; GIG25; Growth inhibiting protein 24; Growth inhibiting protein 25; Serine (or cysteine) proteinase inhibitor clade A member 3; Serine proteinase inhibitor clade A member 3; Serpin A3; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3; anti-SERPINA3 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1 / Kappa
Clone Number
AACT/1452
Specificity
It recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). AACT is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the test of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACT antibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity.
Form/Format
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Applicable Applications for anti-SERPINA3 antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant human Antichymotrypsin (AACT) protein fragment (around aa 49-187) (exact sequence is proprietary)
Cellular Localization
Secreted
Positive Control
HeLa cells. Tonsil, pancreas or histiocytoma.
Research Areas
Cardiovascular, Immunology
Preparation and Storage
Antibody with azide - store at 2 to 8°CC. Antibody without azide - store at -20 to -80°C. Non- hazardous. No MSDS required.
Application Data
(Formalin-fixed, paraffin-embedded human Pancreas stained with Alpha-1- Antichymotrypsin Mouse Monoclonal Antibody (AACT/1452))
Application Data
(Formalin-fixed, paraffin-embedded human Pancreas stained with Alpha-1- Antichymotrypsin Mouse Monoclonal Antibody (AACT/1452))
SDS-PAGE
(SDS-PAGE Analysis of Purified Alpha-1-Antichymotrypsin Monoclonal Antibody (AACT/1452). Confirmation of Integrity and Purity of Antibody.)
SDS-PAGE
(SDS-PAGE Analysis of Purified Alpha-1-Antichymotrypsin Monoclonal Antibody (AACT/1452). Confirmation of Integrity and Purity of Antibody.)
References
Miyake, H., et al. 2001. Value of prostate specific antigen alpha1-antichymotrypsin complex for the detection of prostate cancer in patients with a PSA level of 4.1-10.0 ng/mL: comparison with PSA-related parameters. Int. J. Urol. 8: 589-593.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Mol. Weight of Antigen: 65-76kDa
NCBI Official Full Name
alpha-1-antichymotrypsin
NCBI Official Synonym Full Names
serpin family A member 3
NCBI Official Symbol
SERPINA3
NCBI Official Synonym Symbols
ACT; AACT; GIG24; GIG25
NCBI Protein Information
alpha-1-antichymotrypsin
UniProt Protein Name
Alpha-1-antichymotrypsin
UniProt Gene Name
SERPINA3
UniProt Synonym Gene Names
AACT; ACT
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Product Notes
The SERPINA3 serpina3 (Catalog #AAA62933) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Alpha-1-Antichymotrypsin (SERPINA3) (Histiocytoma Marker) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Alpha-1-Antichymotrypsin (SERPINA3) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the SERPINA3 serpina3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Alpha-1-Antichymotrypsin (SERPINA3), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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