Mouse FAS Monoclonal Antibody | anti-FAS antibody

Mouse Anti Human FAS (CD95) Blocking

Cat. Num. AAA37927

• Gene Names: FASN; FAS; OA-519; SDR27X1
• Applications: ELISA
• Purity: Ion exchange column Protein concentration1 mg/ml in PBS (after reconstitution).
• Synonyms: FAS, Antibody; Mouse Anti Human FAS (CD95) Blocking; FAS Antibody; FAS Blocking Antibody (CD95), Mouse anti Human; FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; CD95; Tumor necrosis factor receptor superfamily member 6 TNR6; APT1; FAS1; TNFRSF6; anti-FAS antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: NYRhFAS
• Purity/Purification: Ion exchange column Protein concentration1 mg/ml in PBS (after reconstitution).
• Sequence Length: 2511

• Applicable Applications for anti-FAS antibody: ELISA
• Additional Information: This is a BLOCKING antibody and will block FAS-mediated apoptosis.
• Reconstitution: Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
• Immunogen: Recombinant Human FAS.
• Preparation and Storage: In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.; Antibody is shipped lyophilized at ambient temperature.

Related Product Information for anti-FAS antibody

Introduction: The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that Fas-mediated apoptosis removes self-reactive lymphocytes. Fas signaling is also involved in immune surveillance to remove transformed cells and virus infected cells. Binding of FAS to oligimerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade. Caspase-8 and caspase-10 are first activated, to then cleave and activate downstream caspases, and a variety of cellular substrates that lead to cell death. Caspases cleave nuclear lamins, causing the nucleus to break down and lose its normal structure and another caspase substrate is DFF, inducing cleavage and degradation of the genome. Other caspase substrates are involved in cytoskeletal structure, cell cycle regulation and signaling pathways. Activation of JNK kinase, activation of Jun, and production of ceramide may also play roles in Fas-mediated apoptosis. Activation of fas-mediated apoptosis is opposed by I-FLICE and FAP. Viruses and tumors may escape immune surveillance in part through suppression of fas-mediated apoptosis using similar mechanisms.

Product Categories/Family for anti-FAS antibody

Anti-Human CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine

NCBI and Uniprot Product Information

• NCBI GI #: 41872631
• NCBI GeneID: 2194
• NCBI Accession #: NP_004095.4
• NCBI GenBank Nucleotide #: NM_004104.4
• Molecular Weight: 273,427 Da
• NCBI Official Full Name: fatty acid synthase
• NCBI Official Synonym Full Names: fatty acid synthase
• NCBI Official Symbol: FASN
• NCBI Official Synonym Symbols: FAS; OA-519; SDR27X1
• NCBI Protein Information: fatty acid synthase; short chain dehydrogenase/reductase family 27X, member 1
• UniProt Protein Name: Fatty acid synthase
• UniProt Gene Name: FASN
• UniProt Synonym Gene Names: FAS
• UniProt Entry Name: FAS_HUMAN