IHC (Immunohiostchemistry)
(IDH1 Antibody Immunohistochemistry on an FFPE Glioblastoma Tissue)
Rabbit anti-Human IDH1 R132H Monoclonal Antibody | anti-IDH1 antibody
IDH1 R132H (RBT-IDH1)
Reactivity
Human
Synonyms
IDH1 R132H, Antibody; IDH1 R132H (RBT-IDH1); idh1; anti-idh1; r132h; anti-r132h; idh-1; idh 1; anti-idh-1; anti-idh; anti-IDH1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT-IDH1
Form/Format
Paraffin, Frozen
IDH1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
IDH1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to IDH1 R132H mutant.
Control
Glioma
Localization
Cytoplasmic
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
IHC (Immunohiostchemistry)
(IDH1 Antibody Immunohistochemistry on an FFPE Glioblastoma Tissue)
IHC (Immunohiostchemistry)
(IDH1 Antibody Immunohistochemistry on an FFPE Glioblastoma Tissue)
Dilution Info
Dilution Info
Related Product Information for anti-IDH1 antibody
IDH1 is an isocitrate dehydrogenase isozymes and encoded by the gene IDH1. IDH1 is involved in the citric acid cycle during glucose metabolism and catalyzes the oxidation of isocitrate to ?-ketoglutarate and reduction of NADP+ to NADPH. Both ?-ketoglutarate and NADPH play a role in protecting cells from oxidative stress and mitigating oxidative damage. Mutation in residue 132 of IDH1 results in loss of enzymatic function, build up of 2-hydroxyglutarate, and change in histone and DNA methylation.
Mutation of IDH1 is implicated in metaphyseal chondromatosis with aciduria as well as diffused gliomas and a number of neoplasms such as acute myeloid leukemia, acute lymphocytic leukemia, myelofibrosis, intrahepatic cholangiocarcinoma, melanoma, chondroid tumors, and certain rare forms of colonic and prostate carcinomas. However studies have shown that IDH1 mutation is not a direct trigger of oncogenesis, but strongly associated with other tumor-promoting mutations. Screening for IDH1 mutation can provide valuable information on identification and prognosis of glioma. Glioma with IDH1 mutation tend to be less aggressive than glioma without IDH1 mutation.
Mutation of IDH1 is implicated in metaphyseal chondromatosis with aciduria as well as diffused gliomas and a number of neoplasms such as acute myeloid leukemia, acute lymphocytic leukemia, myelofibrosis, intrahepatic cholangiocarcinoma, melanoma, chondroid tumors, and certain rare forms of colonic and prostate carcinomas. However studies have shown that IDH1 mutation is not a direct trigger of oncogenesis, but strongly associated with other tumor-promoting mutations. Screening for IDH1 mutation can provide valuable information on identification and prognosis of glioma. Glioma with IDH1 mutation tend to be less aggressive than glioma without IDH1 mutation.
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Product Notes
The IDH1 (Catalog #AAA59376) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IDH1 R132H (RBT-IDH1) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "IDH1 R132H, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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