Rabbit Bcl-10 Polyclonal Antibody | anti-BCL10 antibody

Bcl-10 Antibody

Cat. Num. AAA39497

• Gene Names: BCL10; CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: Bcl-10 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Bcl-10, Antibody; Bcl-10 Antibody; Bcl-10; CLAP; mE10; CIPER; c-E10; CARMEN; CARD-containing molecule enhancing NF-kappa-B; B-cell CLL/lymphoma 10; anti-BCL10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Bcl-10 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Sequence Length: 1413

• Applicable Applications for anti-BCL10 antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Bcl10 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Bcl10.
• Buffer: Bcl-10 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Bcl-10 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of Bcl-10 in Raji cells with Bcl-10 antibody at 10 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry of Bcl10 in Raji cells with Bcl10 antibody at 1 μg/mL.)

WB (Western Blot)

(Western blot analysis of Bcl-10 in Raji whole cell lysate in the absence (A) or presence (B) of peptide (2161P) with Bcl-10 antibody at 1:500 dilution.)

Related Product Information for anti-BCL10 antibody

Bcl-10 Antibody: Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-κB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.

NCBI and Uniprot Product Information

• NCBI GI #: 5070371
• NCBI GeneID: 8915
• UniProt Accession #: O95999; Q5VUF1
• Molecular Weight: 31 kDa
• NCBI Official Full Name: Homo sapiens CARD-like apoptotic protein (CLAP) mRNA, complete cds
• NCBI Official Synonym Full Names: B-cell CLL/lymphoma 10
• NCBI Official Symbol: BCL10
• NCBI Official Synonym Symbols: CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
• NCBI Protein Information: B-cell lymphoma/leukemia 10; hCLAP; cCARMEN; cellular-E10; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-containing molecule enhancing NF-kappa-B; mammalian CARD-containing adapter molecule E10; CED-3/ICH-1 prodomain homologous E10-like regulator
• UniProt Protein Name: B-cell lymphoma/leukemia 10
• UniProt Gene Name: BCL10
• UniProt Synonym Gene Names: CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10
• UniProt Entry Name: BCL10_HUMAN