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IF (Immunofluorescence)
Rabbit CD163 Polyclonal Antibody | anti-CD163 antibody
CD163 Antibody
Gene Names
CD163; M130; MM130; SCARI1
Reactivity
Human, Monkey
Applications
Western Blot, Immunoprecipitation, Immunofluorescence, Immunohistochemistry, ELISA
Synonyms
CD163, Antibody; CD163 Antibody; CD163 antigen; CD163 molecule; Hemoglobin Scavenger Receptor; Macrophage associated antigen; MM130; Scavenger receptor cysteine rich type 1 protein M130; sCD163; Soluble CD163 antibody; anti-CD163 antibody
Host
Rabbit
Reactivity
Human, Monkey
Clonality
Polyclonal
Form/Format
Affinity Purified
Concentration
0.55-0.75 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
994
Applicable Applications for anti-CD163 antibody
WB (Western Blot), IP (Immunoprecipitation), IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA
Immunogen
Synthetic peptide taken within amino acid region 600-650 on human CD163 protein.
Expression
Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
Determinant
N-epitope
Molecular Function
Scavenger receptor activity
Structure
Interacts with CSNK2B.
Subcellular Location
Membrane
Preparation and Storage
-20 degree C for long term storage
IF (Immunofluorescence)
IF (Immunofluorescence)
IF (Immunofluorescence)
IF (Immunofluorescence)
IF (Immunofluorescence)
IF (Immunofluorescence)
IF (Immunofluorescence)
IF (Immunofluorescence)
IHC (Immunohistochemistry)
IHC (Immunohistochemistry)
Related Product Information for anti-CD163 antibody
Affinity Purified CD163 Antibody N-epitope
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable parameter for monitoring macrophage activation in inflammatory conditions.
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable parameter for monitoring macrophage activation in inflammatory conditions.
Product Categories/Family for anti-CD163 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
107,419 Da
NCBI Official Full Name
CD163 antigen, isoform CRA_a
NCBI Official Synonym Full Names
CD163 molecule
NCBI Official Symbol
CD163
NCBI Official Synonym Symbols
M130; MM130; SCARI1
NCBI Protein Information
scavenger receptor cysteine-rich type 1 protein M130
UniProt Protein Name
CD163 antigen, isoform CRA_a
UniProt Gene Name
CD163
UniProt Entry Name
D3DUU0_HUMAN
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Product Notes
The CD163 cd163 (Catalog #AAA75822) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD163 Antibody reacts with Human, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's CD163 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IP (Immunoprecipitation), IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the CD163 cd163 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD163, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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