Rabbit anti-Human p40 Polyclonal Antibody | anti-p40 antibody

p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker)

Cat. Num. AAA215271

• Gene Names: TP63; AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: p40, Antibody; p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker); deltaNp63; TP63; anti-p40 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: p40 (p63 delta) is a marker recently determined to be highly specific for squamous basal cells in the immunohistochemistry (IHC) application. The current more routinely recommended marker, p63, appears to have less specificity compared to p40, especially on squamous cell tumors. The ability to differentiate between lung adenocarcinoma vs. squamous cell carcinoma is difficult and has bearing on the different therapeutic avenues for each subtype treatment. p63 antibody s ability to distinguish between the tumor types appears to be inferior when compared to p40. The ability to utilize an antibody probe for p40 as a squamous cell marker bolsters its use for future sub-classification of lung cancers, especially by immunohistochemical techniques.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 555

• Applicable Applications for anti-p40 antibody: IHC (Immunohistochemistry)
• Positive Control: Human prostate or lung tissue (IHC).
• Immunogen: Recombinant human p40 protein fragment
• Cellular Localization: Nuclear
• Hu-chromosome Location: 3q28
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded Cervix stained with p40 Rabbit Polyclonal Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with p40 Rabbit Polyclonal Antibody.)

References

1. Terry J, et al. Am J Surg Pathol. 2010; 34(12):1805-11. 2. Signoretti S, et al. Am J Pathol. 2000; 157(6):1769-75.

NCBI and Uniprot Product Information

• NCBI GI #: 169234657
• NCBI GeneID: 8626
• NCBI Accession #: NP_001108450.1
• NCBI GenBank Nucleotide #: NP_001108450.1
• UniProt Accession #: Q9H3D4
• Molecular Weight: 40kDa
• NCBI Official Full Name: tumor protein 63 isoform 2
• NCBI Official Synonym Full Names: tumor protein p63
• NCBI Official Symbol: TP63
• NCBI Official Synonym Symbols: AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)
• NCBI Protein Information: tumor protein 63
• UniProt Protein Name: Tumor protein 63
• UniProt Gene Name: TP63
• UniProt Synonym Gene Names: KET; P63; P73H; P73L; TP73L; p63; CUSP; TP63; p73L
• UniProt Entry Name: P63_HUMAN