IF (Immunofluorescence)
(Immunofluorescence of SIRT1 in rat lung tissue with SIRT1 antibody at 20 ug/mL.)
Rabbit SIRT1 Polyclonal Antibody | anti-SIRT1 antibody
SIRT1 Antibody
Gene Names
SIRT1; SIR2; hSIR2; SIR2L1
Reactivity
Human, Mouse, Rat
Applications
Immunofluorescence, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
SIRT1, Antibody; SIRT1 Antibody; Sirtuin, NAD-dependent deacetylase sirtuin-1, SIR2L1, hSIR2, hSIRT1; anti-SIRT1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
747
Applicable Applications for anti-SIRT1 antibody
IF (Immunofluorescence), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 19 amino acid peptide near the amino terminus of human SIRT1.
Target Name
SIRT1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IF (Immunofluorescence)
(Immunofluorescence of SIRT1 in rat lung tissue with SIRT1 antibody at 20 ug/mL.)
IF (Immunofluorescence)
(Immunofluorescence of SIRT1 in rat lung tissue with SIRT1 antibody at 20 ug/mL.)
WB (Western Blot)
(Western blot analysis of SIRT1 in mouse liver tissue lysate with SIRT1 antibody at 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of SIRT1 in mouse liver tissue lysate with SIRT1 antibody at 1 ug/mL.)
Related Product Information for anti-SIRT1 antibody
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically via lysine residue.
Product Categories/Family for anti-SIRT1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
61,066 Da
NCBI Official Full Name
NAD-dependent protein deacetylase sirtuin-1 isoform a
NCBI Official Synonym Full Names
sirtuin 1
NCBI Official Symbol
SIRT1
NCBI Official Synonym Symbols
SIR2; hSIR2; SIR2L1
NCBI Protein Information
NAD-dependent protein deacetylase sirtuin-1
UniProt Protein Name
NAD-dependent protein deacetylase sirtuin-1
UniProt Gene Name
SIRT1
UniProt Synonym Gene Names
SIR2L1; hSIRT1; hSIR2; 75SirT1
UniProt Entry Name
SIR1_HUMAN
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Product Notes
The SIRT1 sirt1 (Catalog #AAA305165) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIRT1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SIRT1 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the SIRT1 sirt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIRT1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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