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IHC (Immunohistochemistry)
(Anti- STIM1 Picoband antibody, PB9406, IHC(P)IHC(P): Human Mammary Cancer Tissue)
Rabbit STIM1 Polyclonal Antibody | anti-STIM1 antibody
Anti-STIM1 Antibody
Gene Names
STIM1; GOK; TAM; TAM1; IMD10; STRMK; D11S4896E
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Immunogen Affinity Purified
Synonyms
STIM1, Antibody; Anti-STIM1 Antibody; Stromal interaction molecule 1; D11S4896E; GOK; OTTHUMP00000164512; OTTHUMP00000229140; OTTHUMP00000230742; stromal interaction molecule 1; anti-STIM1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
No cross reactivity with other proteins.
Purity/Purification
Immunogen Affinity Purified
Form/Format
Lyophilized; Contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
540
Applicable Applications for anti-STIM1 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human STIM1(45-74aa AAEFCRIDKPLCHSEDEKLSFEAVRNIHKL), identical to the related mouse and rat sequences.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
IHC (Immunohistochemistry)
(Anti- STIM1 Picoband antibody, PB9406, IHC(P)IHC(P): Human Mammary Cancer Tissue)
IHC (Immunohistochemistry)
(Anti- STIM1 Picoband antibody, PB9406, IHC(P)IHC(P): Human Mammary Cancer Tissue)
IHC (Immunohistochemisry)
(Anti- STIM1 Picoband antibody, PB9406, IHC(P)IHC(P): Rat Intestine Tissue)
IHC (Immunohistochemisry)
(Anti- STIM1 Picoband antibody, PB9406, IHC(P)IHC(P): Rat Intestine Tissue)
IHC (Immunohiostchemistry)
(Anti- STIM1 Picoband antibody, PB9406, IHC(P)IHC(P): Mouse Intestine Tissue)
IHC (Immunohiostchemistry)
(Anti- STIM1 Picoband antibody, PB9406, IHC(P)IHC(P): Mouse Intestine Tissue)
WB (Western Blot)
(Anti- STIM1 Picoband antibody, PB9406, Western blottingAll lanes: Anti STIM1 at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Mouse Liver Tissue Lysate at 50ugLane 3: Human Placenta Tissue Lysate at 50ugLane 4: HELA Whole Cell Lysate at 40ugLane 5: SMMC Whole Cell Lysate at 40ugLane 6: HEPG2 Whole Cell Lysate at 40ugPredicted bind size: 77KDObserved bind size: 100KD)
WB (Western Blot)
(Anti- STIM1 Picoband antibody, PB9406, Western blottingAll lanes: Anti STIM1 at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Mouse Liver Tissue Lysate at 50ugLane 3: Human Placenta Tissue Lysate at 50ugLane 4: HELA Whole Cell Lysate at 40ugLane 5: SMMC Whole Cell Lysate at 40ugLane 6: HEPG2 Whole Cell Lysate at 40ugPredicted bind size: 77KDObserved bind size: 100KD)
Related Product Information for anti-STIM1 antibody
Description: Rabbit IgG polyclonal antibody for Stromal interaction molecule 1(STIM1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Background: Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. STIM1 has a single transmembranedomain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane. This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
Background: Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. STIM1 has a single transmembranedomain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane. This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
References
1. Parker NJ, Begley CG, Smith PJ, Fox RM (Feb 1997). "Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5". Genomics 37 (2): 253-6. 2. Soboloff, Jonathan; Rothberg, B. S.; Madesh, M.; Gill, D. L. (September 2012)."STIM proteins: dynamic calcium signal transducers". Nat Rev Mol Cell Biol 13 (9): 549-65. 3. Williams RT, Manji SS, Parker NJ, Hancock MS, Van Stekelenburg L, Eid JP, Senior PV, Kazenwadel JS, Shandala T, Saint R, Smith PJ, Dziadek MA (Jul 2001)."Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins". Biochem J 357 (Pt 3): 673-85.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
stromal interaction molecule 1 isoform 3
NCBI Official Synonym Full Names
stromal interaction molecule 1
NCBI Official Symbol
STIM1
NCBI Official Synonym Symbols
GOK; TAM; TAM1; IMD10; STRMK; D11S4896E
NCBI Protein Information
stromal interaction molecule 1
UniProt Protein Name
Stromal interaction molecule 1
UniProt Gene Name
STIM1
UniProt Entry Name
STIM1_HUMAN
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Product Notes
The STIM1 stim1 (Catalog #AAA46528) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-STIM1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's STIM1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the STIM1 stim1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "STIM1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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